Reversing effect of ring finger protein 43 inhibition on malignant phenotypes of human hepatocellular carcinoma

It has been shown that Ring finger protein 43 (RNF43) is overexpressed in colorectal cancer and mediates cancer cell proliferation; however, its role in hepatocellular carcinoma (HCC) remains unknown. In this study, we found that RNF43 was frequently overexpressed in HCCs, and this overexpression wa...

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Bibliographic Details
Published in:Molecular cancer therapeutics 2013-01, Vol.12 (1), p.94-103
Main Authors: Xing, Chunyang, Zhou, Wuhua, Ding, Songming, Xie, Haiyang, Zhang, Wu, Yang, Zhe, Wei, Bajin, Chen, Kangjie, Su, Rong, Cheng, Jun, Zheng, Shusen, Zhou, Lin
Format: Article
Language:English
Subjects:
Adult
Aged
Animals
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - pathology
Cell Adhesion
Cell Line, Tumor
Cell Movement
Cell Proliferation
Cell Survival
Cell Transformation, Neoplastic - metabolism
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Extracellular Matrix - metabolism
Female
Gene Knockdown Techniques
Humans
Liver Neoplasms - metabolism
Liver Neoplasms - pathology
Male
Matrix Metalloproteinases - metabolism
Mice
Mice, Inbred BALB C
Mice, Nude
Middle Aged
Neoplasm Transplantation
Oncogene Proteins - genetics
Oncogene Proteins - metabolism
Phenotype
RNA, Small Interfering - genetics
Transcriptome - drug effects
Tumor Burden
Young Adult
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Summary:It has been shown that Ring finger protein 43 (RNF43) is overexpressed in colorectal cancer and mediates cancer cell proliferation; however, its role in hepatocellular carcinoma (HCC) remains unknown. In this study, we found that RNF43 was frequently overexpressed in HCCs, and this overexpression was correlated with positive vascular invasion, poor tumor differentiation, and advanced tumor stage. Functional studies showed that knockdown of RNF43 could induce apoptosis and inhibit proliferation, invasion, colony formation, and xenograft growth of HCCs. Microarray-based gene profiling showed a total of 229 genes differentially expressed after RNF43 knockdown, many of which are involved in oncogenic processes such as cell proliferation, cell adhesion, cell motility, cell death, DNA repair, and so on. These results suggest that RNF43 is involved in tumorigenesis and progression of HCCs and that antagonism of RNF43 may be beneficial for HCC treatment.
ISSN:1535-7163
1538-8514
DOI:10.1158/1535-7163.MCT-12-0672