Epinephrine (adrenaline) absorption from new-generation, taste-masked sublingual tablets: A preclinical study

[...]many patients at risk of anaphylaxis do not carry their epinephrine autoinjectors with them consistently because of bulky autoinjector size. [...]when anaphylaxis occurs, epinephrine autoinjectors are underused, even by patients who have life-threatening respiratory or cardiovascular symptoms.

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2013-01, Vol.131 (1), p.236-238
Main Authors: Rachid, Ousama, BPharm, MSc, Rawas-Qalaji, Mutasem M., PhD, Simons, F. Estelle R., MD, Simons, Keith J., PhD
Format: Article
Language:English
Subjects:
Administration, Sublingual
Allergy and Immunology
Animals
Biological and medical sciences
Cellulose
Colleges & universities
Drug Evaluation, Preclinical
Epinephrine - administration & dosage
Epinephrine - pharmacokinetics
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Human subjects
Immunopathology
Medical sciences
Molecular weight
Plasma
Rabbits
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Tablets
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Description
Summary:[...]many patients at risk of anaphylaxis do not carry their epinephrine autoinjectors with them consistently because of bulky autoinjector size. [...]when anaphylaxis occurs, epinephrine autoinjectors are underused, even by patients who have life-threatening respiratory or cardiovascular symptoms.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2012.10.016