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Lung function in young adults with congenital diaphragmatic hernia; a longitudinal evaluation

Background Survival rates of patients with congenital diaphragmatic hernia (CDH) have improved to up to 80%. Little is known about long‐term consequences of the disease and its treatment. We evaluated lung function and respiratory symptoms longitudinally in a previously studied cohort of CDH patient...

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Bibliographic Details
Published in:Pediatric pulmonology 2013-02, Vol.48 (2), p.130-137
Main Authors: Spoel, Marjolein, van der Cammen-van Zijp, Monique H.M., Hop, Wim C.J., Tibboel, Dick, de Jongste, Johan C., IJsselstijn, Hanneke
Format: Article
Language:English
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Summary:Background Survival rates of patients with congenital diaphragmatic hernia (CDH) have improved to up to 80%. Little is known about long‐term consequences of the disease and its treatment. We evaluated lung function and respiratory symptoms longitudinally in a previously studied cohort of CDH patients and age‐matched non‐CDH patients who underwent similar neonatal intensive care treatment. Study Design We tested 27 young adults [mean (SD) age: 26.8 years (2.9)] with CDH and 30 non‐CDH patients. Dynamic and static lung volumes, midexpiratory flows, and diffusion capacity were expressed as mean (SD) standard deviation scores. Prevalence of respiratory symptoms was evaluated with the European Community Respiratory Health Survey. Results All data are expressed as mean (SD). FEF25–75 in CDH patients had slightly deteriorated since childhood (CDH: −0.7 (1.4) vs. −1.6 (1.5), P 
ISSN:8755-6863
1099-0496
DOI:10.1002/ppul.22557