Expression of NRF2 and NRF2-modulated genes in peripheral blood leukocytes of bladder cancer males

Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is an oxidant-responsive transcription factor involved in induction of antioxidant genes. We assessed NRF2 and selected NRF2-modulated gene expression: glutathione S-transferase A1 and P1 (GSTA1 and GSTP1), mitochondrial superoxide dismutase (SOD2)...

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Bibliographic Details
Published in:Neoplasma 2013-01, Vol.60 (2), p.123-128
Main Authors: Reszka, E, Jablonowski, Z, Wieczorek, E, Gromadzinska, J, Jablonska, E, Sosnowski, M, Wasowicz, W
Format: Article
Language:English
Subjects:
Aged
Gene Expression Regulation, Neoplastic
Glutathione S-Transferase pi - genetics
Glutathione Transferase - genetics
Humans
Leukocytes - metabolism
Male
Middle Aged
NF-E2-Related Factor 2 - genetics
NF-E2-Related Factor 2 - physiology
RNA, Messenger - analysis
Superoxide Dismutase - genetics
Urinary Bladder Neoplasms - genetics
Urinary Bladder Neoplasms - metabolism
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Summary:Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is an oxidant-responsive transcription factor involved in induction of antioxidant genes. We assessed NRF2 and selected NRF2-modulated gene expression: glutathione S-transferase A1 and P1 (GSTA1 and GSTP1), mitochondrial superoxide dismutase (SOD2) in blood leukocytes of 51 bladder cancer patients and 90 control males. A significant up-regulation of SOD2 expression (P=0.002) was observed in leukocytes of patients. NRF2 expression was positively correlated with GSTP1 and with SOD2 mRNA level, both in patients and controls. These data suggest disturbances in SOD2 transcription in circulating blood leukocytes of males with bladder cancer. Moreover, concomitant constitutive expression of NRF2 and its target genes may suggest important role of NRF2 transcription factor in positive regulation of antioxidant genes, resulted in enhanced cytoprotection in human peripheral blood leukocytes.
ISSN:0028-2685
DOI:10.4149/neo_2013_016