Effect of Coenzyme Q10 on Proteomic Profile of Blood Plasma and Cytosolic and Microsomal Fractions of Rat Hepatocytes during Ontogeny

The proteomic features of blood plasma and subcellular fractions of rat hepatocytes were studied during long-term dietary consumption of coenzyme Q10 as the endogenous mediator of antioxidant and energy homeostasis in the cell. Long-term coenzyme Q10 consumption was followed by the formation of spec...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2012-11, Vol.154 (1), p.30-33
Main Authors: Sharanova, N. E., Toropygin, I. Yu, Khriapova, E. V., Vasilyev, A. V., Gapparov, M. M. G.
Format: Article
Language:English
Subjects:
Animals
Antioxidants - administration & dosage
Antioxidants - pharmacology
Biomedical and Life Sciences
Biomedicine
Biophysics and Biochemistry
Cell Biology
Cytosol
Enzymes
Hepatocytes - cytology
Hepatocytes - drug effects
Hepatocytes - metabolism
Internal Medicine
Laboratory Medicine
Liver - drug effects
Liver - metabolism
Male
Microsomes - drug effects
Microsomes - metabolism
Pathology
Plasma - drug effects
Plasma - physiology
Proteome - metabolism
Proteomics
Rats
Rats, Wistar
Subcellular Fractions - metabolism
Ubiquinone - administration & dosage
Ubiquinone - analogs & derivatives
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Summary:The proteomic features of blood plasma and subcellular fractions of rat hepatocytes were studied during long-term dietary consumption of coenzyme Q10 as the endogenous mediator of antioxidant and energy homeostasis in the cell. Long-term coenzyme Q10 consumption was followed by the formation of specific nutriproteomes of the microsomal and cytosolic fractions of rat hepatocytes.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-012-1867-5