Possible Aspects of Using Cultured Stem Cell of Laboratory Primates in Experimental Medicine

We describe the methods of isolation and culturing of mesenchymal stem cells from 3 monkey species Macaca mulatta , Papio hamadryas , and Macaca fascicularis . Flow cytofl uorometry showed that the cells do not express CD34, CD45, and HLA-DR, but most of them (78-98%) express CD90 marker. The cardio...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2012-11, Vol.154 (1), p.133-135
Main Authors: Agrba, V. Z., Porkhanov, V. A., Konoplyannikov, A. G., Kal’sina, S. Sh, Karal-ogly, D. D., Ignatova, I. E., Gvozdik, T. E., Agumava, A. A., Leontiuk, A. V., Lapin, B. A.
Format: Article
Language:English
Subjects:
Animals
Antigens, CD34 - metabolism
Azacitidine
Biomedical and Life Sciences
Biomedicine
Cardiomyopathies - chemically induced
Cardiomyopathies - prevention & control
Cardiomyopathies - therapy
Cell Biology
Cell Culture Techniques
Cell Differentiation
Cell Separation
Cells, Cultured
Doxorubicin
HLA-DR Antigens - metabolism
Internal Medicine
Laboratory Medicine
Leukocyte Common Antigens - metabolism
Macaca
Macaca fascicularis
Macaca mulatta
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells - cytology
Mesenchymal Stem Cells - metabolism
Papio hamadryas
Pathology
Thy-1 Antigens - metabolism
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Summary:We describe the methods of isolation and culturing of mesenchymal stem cells from 3 monkey species Macaca mulatta , Papio hamadryas , and Macaca fascicularis . Flow cytofl uorometry showed that the cells do not express CD34, CD45, and HLA-DR, but most of them (78-98%) express CD90 marker. The cardioprotective effects of cultured mesenchymal stem cells in cardiomyopathy induced by administration of antitumor anthracycline drugs (doxorubicin).
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-012-1893-3