Comparisons between Bio-Oss® and Straumann® Bone Ceramic in immediate and staged implant placement in dogs mandible bone defects

• Published in: Clinical oral implants research 2013-02, Vol.24 (2), p.135-142
• Main Authors: Antunes, Antonio A., Oliveira Neto, Patricio, de Santis, Enzo, Caneva, Marco, Botticelli, Daniele, Salata, Luiz A.
• Format: Article
• Language: English
• Subjects: Alveolar Bone Loss - prevention & control; animal experiments; Animals; bone implant interactions; bone substitutes; Bone Substitutes - pharmacology; Bone Transplantation - methods; Dental Enamel Proteins - pharmacology; Dental Implantation, Endosseous - methods; Dental Implants; Dentistry; Dogs; Hydroxyapatites - pharmacology; Immediate Dental Implant Loading; Male; Mandible - surgery; Minerals - pharmacology; morphometric analysis; Osseointegration; Wound Healing
• ISSN: 0905-7161; 1600-0501
• DOI: 10.1111/j.1600-0501.2011.02385.x

Objective To compare immediate and staged approach implant placement in circumferential defects treated with deproteinized bovine bone mineral (DBBM); hidroxyapatite/tricalcium phosphate (HA/TP); autogenous bone (Ab); and coagulum (Cg); upon implant stability, osseointegration and alveolar crest maintenance. Materials and methods Six dogs underwent extractions of lower premolars, bilaterally. Twelve weeks later four bone defects (6 mm wide/4 mm long) were drilled at one side and randomly filled with DBBM; HA/TP; Ab; and Cg, respectively, and left to heal (staged approach). Eight weeks later one implant (Osseospeed™, AstraTech) was placed in experimental sites. At the same session four defects were drilled on contra‐lateral side and implants were inserted immediately after biomaterials grafting (immediate approach). Animals were euthanized 8 weeks later. Implant stability was measured by resonance frequency analysis (RFA) at installation and after sacrifice. Ground sections were prepared for bone contact (BIC); bone area (BA); distance implant shoulder‐bone crest (IS‐C); distance implant shoulder first bone contact (IS‐B); and areas occupied by soft tissue. Results The BA and BIC were superior in the staged approach. The Cg exhibited higher BIC and BA as compared with other materials at the total implant body (P = 0.004 and 0.012, respectively). The DBBM, HA/TP and Ab groups rendered similar BA and BIC. The immediate approach resulted in less crest resorption compared to staged approach. The biomaterials did not affect the IS‐C and IS‐B measurements. Particles area tended to be higher in DBBM group than HA/TP (P = 0.15), while soft tissue infiltrate was higher in DBBM group when used in the immediate approach (P = 0.04). The RFA indicated gain in stability in the staged approach (P = 0.002). The correlation test between RFA vs. BIC and BA demonstrated inferior stability for DBBM group in immediate approach (P = 0.01). Conclusions Implants placed in healed defects resulted in better stability as a consequence of higher BIC and BA. The Cg alone rendered increased BIC compared to other materials in both approaches. Immediate approach should be preferable to staged approach in terms of alveolar crest maintenance. The BIC and BA values did not vary between micro and macro‐threads in this experimental model. Implants installed in sites filled with DBBM in immediate approach were less stable.