Prognostic value and differences of the sixth and seventh editions of the UICC/AJCC staging systems in nasopharyngeal carcinoma

Background The aim of this study was to identify the prognostic value and differences between the 6th and 7th International Union Against Cancer/American Joint Committee on Cancer staging systems in nasopharyngeal carcinoma. Methods The magnetic resonance imaging scans and medical records of 903 pat...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 2013-02, Vol.139 (2), p.307-314
Main Authors: Sun, Rui, Qiu, Hui-Zhi, Mai, Hai-Qiang, Zhang, Qing, Hong, Ming-Huang, Li, Yan-Xian, Yang, Jing, Sun, Jian, Mo, Hao-Yuan
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antineoplastic agents
Biological and medical sciences
Cancer Research
Carcinoma
Female
Head & neck cancer
Hematology
Humans
Internal Medicine
Male
Medical prognosis
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms - mortality
Nasopharyngeal Neoplasms - pathology
Nasopharyngeal Neoplasms - radiotherapy
Neoplasm Staging
Oncology
Original Paper
Otorhinolaryngology. Stomatology
Pharmacology. Drug treatments
Prognosis
Treatment Failure
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
Young Adult
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Summary:Background The aim of this study was to identify the prognostic value and differences between the 6th and 7th International Union Against Cancer/American Joint Committee on Cancer staging systems in nasopharyngeal carcinoma. Methods The magnetic resonance imaging scans and medical records of 903 patients with histologically diagnosed non-disseminated nasopharyngeal carcinoma were reviewed retrospectively. Moreover, the extent of nasopharyngeal carcinoma was restaged according to the 6th and 7th editions of the staging systems. Results Among the 903 patients, the 5-year survival rates were as follows: overall survival (OS), 81 %; local relapse-free survival (LRFS), 90 %; distant metastasis-free survival, 86 %; and disease-free survival, 77 %. Using the 7th edition of the staging system, significant differences in OS between categories T1 and T3, categories T1 and T4, categories T2 and T3, and categories T2 and T4 were achieved ( P  
ISSN:0171-5216
1432-1335
DOI:10.1007/s00432-012-1333-9