MSI1 overexpression in diffuse type of gastric cancer

Being the third most frequent cause of cancer mortality in the world, gastric cancer is the major cause of cancer-related mortality in Iran. Musashi1 recognizes a motif in the 3′UTR of target mRNAs – involved in cell cycle regulation, proliferation and apoptosis – and represses the translation of th...

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Bibliographic Details
Published in:Pathology, research and practice research and practice, 2013-01, Vol.209 (1), p.10-13
Main Authors: Nikpour, Parvaneh, Emadi-Baygi, Modjtaba, Mohhamad-Hashem, Faezeh, Maracy, Mohamad Reza, Haghjooy-Javanmard, Shaghayegh
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Female
Gastric cancer
Gene expression
Gene Expression Profiling
Humans
Male
Middle Aged
MSI1
Neoplasm Grading
Neoplasm Staging
Nerve Tissue Proteins - biosynthesis
Nerve Tissue Proteins - genetics
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - analysis
RNA-Binding Proteins - biosynthesis
RNA-Binding Proteins - genetics
Stomach Neoplasms - genetics
Stomach Neoplasms - metabolism
Stomach Neoplasms - pathology
Up-Regulation
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Summary:Being the third most frequent cause of cancer mortality in the world, gastric cancer is the major cause of cancer-related mortality in Iran. Musashi1 recognizes a motif in the 3′UTR of target mRNAs – involved in cell cycle regulation, proliferation and apoptosis – and represses the translation of the mRNAs. As tissue stem cells exist in many adult tissues other than the CNS, Musashi is considered to be associated with many malignancies. In the current study, we aimed to assess Musashi1 gene expression in human stomach cancer. In total, 30 paired gastric tumoral and adjacent non-tumoral tissue specimens were examined for gene expression by qReal-Time RT-PCR. Our results demonstrated that the expression of the gene did not significantly change between tumor/non-tumor tissues (p value: 16×10−2) and different grades (p value: 36×10−2). However, there was a statistical difference between the MSI1 gene expression in different tumor types, i.e., intestinal versus diffuse type (p value: 3×10−2). All together, further investigations should be done to elucidate the precise molecular mechanisms by which MSI1 contribute to the pathogenesis of gastric cancer.
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2012.09.008