Phenolic Compounds from Caesalpinia sappan Heartwood and Their Anti-inflammatory Activity

Four new phenolic compounds, caesalpiniaphenols A–D (1–4), together with eight known compounds were isolated from Caesalpinia sappan heartwood. The chemical structures were established mainly by NMR, MS, ECD, and Mosher’s method. Compounds 4, 5, and 7 showed weak inhibitory activity against the LPS-...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2012-12, Vol.75 (12), p.2069-2075
Main Authors: Cuong, To Dao, Hung, Tran Manh, Kim, Jin Cheol, Kim, Eun Hee, Woo, Mi Hee, Choi, Jae Sue, Lee, Jeong Hyung, Min, Byung Sun
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - chemistry
Anti-Inflammatory Agents, Non-Steroidal - isolation & purification
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Caesalpinia - chemistry
Inhibitory Concentration 50
Lipopolysaccharides - pharmacology
Macrophages - drug effects
Mice
Molecular Structure
Nitric Oxide - analysis
Nitric Oxide - biosynthesis
Nuclear Magnetic Resonance, Biomolecular
Phenols - chemistry
Phenols - isolation & purification
Phenols - pharmacology
Republic of Korea
Wood - chemistry
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Summary:Four new phenolic compounds, caesalpiniaphenols A–D (1–4), together with eight known compounds were isolated from Caesalpinia sappan heartwood. The chemical structures were established mainly by NMR, MS, ECD, and Mosher’s method. Compounds 4, 5, and 7 showed weak inhibitory activity against the LPS-induced NO production in macrophage RAW264.7 cells with IC50 values of 12.2, 3.5, and 5.7 μM, respectively.
ISSN:0163-3864
1520-6025
DOI:10.1021/np3003673