Simultaneous quantification of vinblastine and desacetylvinblastine concentrations in canine plasma and urine samples using LC–APCI–MS/MS

► HLC/MS/MS method to quantitate vinblastine/desacetylvinblastine in canine matrices. ► Linear over wide range of concentrations in plasma and urine, LLOQ 0.125ng/mL. ► Intra and interday accuracy >89% and imprecision

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Bibliographic Details
Published in:Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2013-01, Vol.913-914 (15), p.147-154
Main Authors: Achanta, Satyanarayana, Ngo, Minh, Veitenheimer, Allison, Maxwell, Lara K., Wagner, Jarrad R.
Format: Article
Language:English
Subjects:
ammonium acetate
Analysis
Animals
chromatography
Chromatography, Liquid - methods
Desacetylvinblastine
Dog
Dogs
Drug Stability
LC/MS/MS
Linear Models
metabolites
methanol
monitoring
pharmacokinetics
Reproducibility of Results
solid phase extraction
spectroscopy
Tandem Mass Spectrometry - methods
urine
Vinblastine
Vinblastine - analogs & derivatives
Vinblastine - analysis
Vinblastine - blood
Vinblastine - urine
Vinorelbine
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Description
Summary:► HLC/MS/MS method to quantitate vinblastine/desacetylvinblastine in canine matrices. ► Linear over wide range of concentrations in plasma and urine, LLOQ 0.125ng/mL. ► Intra and interday accuracy >89% and imprecision
ISSN:1570-0232
1873-376X
DOI:10.1016/j.jchromb.2012.11.012