Contrast media volume optimization in high-pitch dual-source CT coronary angiography: feasibility study

To investigate the feasibility of contrast media (CM) volume reduction in dual-source coronary computed tomography angiography high-pitch mode without affecting coronary artery enhancement. Eighty patients were involved in a preliminary experiment with a default injection protocol (60 ml of CM). The...

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Bibliographic Details
Published in:The International Journal of Cardiovascular Imaging 2013-01, Vol.29 (1), p.245-252
Main Authors: Yang, Wen Jie, Chen, Ke Min, Liu, Bo, Pang, Li Fang, Zhang, Huan, Pan, Zi Lai, Yan, Fu Hua
Format: Article
Language:English
Subjects:
Aged
Algorithms
Analysis of Variance
Cardiac Imaging
Cardiology
Contrast Media - administration & dosage
Coronary Angiography - methods
Coronary Sinus - diagnostic imaging
Coronary Vessels - diagnostic imaging
Feasibility Studies
Female
Humans
Imaging
Iopamidol - administration & dosage
Linear Models
Male
Medicine
Medicine & Public Health
Middle Aged
Original Paper
Predictive Value of Tests
Radiographic Image Interpretation, Computer-Assisted
Radiology
Tomography, X-Ray Computed
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Summary:To investigate the feasibility of contrast media (CM) volume reduction in dual-source coronary computed tomography angiography high-pitch mode without affecting coronary artery enhancement. Eighty patients were involved in a preliminary experiment with a default injection protocol (60 ml of CM). The age, BMI, test bolus (TB) enhancement peak and the CT values of coronary artery for each patient were recorded and the key factors for determining coronary artery enhancement were investigated. Based on the results of the preliminary experiment, 120 patients were involved in the main experiment with a new injection protocol. For each patient, the CT values and noise of left coronary sinus (LCS), and the distal segment of right coronary artery were measured. In the preliminary experiment, the peak enhancement of TB correlated most strongly with the HU values of coronary artery. Consequently, the new injection protocol was devised to catalog patients into four groups (30, 40, 50 and 60 ml) of CM based on their TB peak enhancement. In the main experiment, the 30 ml CM injection group whose peak attenuation of TB were the highest (30 vs. 40,50,60 ml: 323.0 ± 27.5 vs. 264.2 ± 11.9, 242.1 ± 8.8, 206.2 ± 18.2 HU, p  
ISSN:1569-5794
1573-0743
1875-8312
DOI:10.1007/s10554-012-0068-7