Downregulation of CCR5 Expression on the Peripheral Blood CD8+ T Cells of Southeastern Iranian Patients with Chronic Hepatitis B Infection

Studies indicated that CC receptor 5 (CCR5), as a receptor for CC ligand 3, CCL4, and CCL5, plays important roles in the recruitment of T cytotoxic lymphocytes to the liver of chronic HBV (CHB)-infected patients. The main purpose of this study was to investigate the expression levels of CCR5 on the...

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Bibliographic Details
Published in:Inflammation 2013-02, Vol.36 (1), p.136-140
Main Authors: Ahmadabadi, Behzad Nasiri, Hassanshahi, Gholamhossein, Khoramdelazad, Hossein, Mirzaei, Vahid, Sajadi, Seyed Mohammad Ali, Hajghani, Masomeh, Khodadadi, Hassan, Pourali, Reza, Arababadi, Mohammad Kazemi, Kennedy, Derek
Format: Article
Language:English
Subjects:
Adult
Alanine Transaminase - blood
Alkaline Phosphatase - blood
Aspartate Aminotransferases - blood
Bilirubin - blood
Biomedical and Life Sciences
Biomedicine
CD8-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - metabolism
Cell Movement
DNA, Viral - analysis
Down-Regulation
Female
Gene Expression
Hepatitis B virus - immunology
Hepatitis B virus - isolation & purification
Hepatitis B, Chronic - blood
Hepatitis B, Chronic - immunology
Hepatitis B, Chronic - virology
Humans
Immunology
Internal Medicine
Iran
Liver - immunology
Liver - virology
Liver Function Tests
Male
Pathology
Pharmacology/Toxicology
Receptors, CCR5 - biosynthesis
Rheumatology
T-Lymphocytes, Cytotoxic - immunology
T-Lymphocytes, Cytotoxic - metabolism
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Summary:Studies indicated that CC receptor 5 (CCR5), as a receptor for CC ligand 3, CCL4, and CCL5, plays important roles in the recruitment of T cytotoxic lymphocytes to the liver of chronic HBV (CHB)-infected patients. The main purpose of this study was to investigate the expression levels of CCR5 on the CD8 + T lymphocytes of CHB patients. This clinical study was performed on 63 CHB patients and 96 healthy controls. Flow cytometric analysis was performed to examine the expression of CCR5 on CD8 + T cells of CHB patients. Real-time PCR was also used for HBV-DNA quantification. The results of our study demonstrated that CCR5 expressing T cytotoxic cells were decreased significantly in CHB patients in comparison to healthy control. Based on our results, it can be concluded that the percent of CCR5 + /CD8 + T cells in Iranian CHB patients is significantly decreased, hence their migration to the infected liver, and HBV eradication from the hepatocytes is disrupted.
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-012-9528-4