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Downregulation of CCR5 Expression on the Peripheral Blood CD8+ T Cells of Southeastern Iranian Patients with Chronic Hepatitis B Infection
Studies indicated that CC receptor 5 (CCR5), as a receptor for CC ligand 3, CCL4, and CCL5, plays important roles in the recruitment of T cytotoxic lymphocytes to the liver of chronic HBV (CHB)-infected patients. The main purpose of this study was to investigate the expression levels of CCR5 on the...
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| Published in: | Inflammation 2013-02, Vol.36 (1), p.136-140 |
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| Main Authors: | , , , , , , , , , |
| Format: | Article |
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| cites | cdi_FETCH-LOGICAL-c344t-ad19799f10ca42326f2db29e3aef5a87f7008a8dc1d3b358de4590b8d4f04c643 |
| container_end_page | 140 |
| container_issue | 1 |
| container_start_page | 136 |
| container_title | Inflammation |
| container_volume | 36 |
| creator | Ahmadabadi, Behzad Nasiri Hassanshahi, Gholamhossein Khoramdelazad, Hossein Mirzaei, Vahid Sajadi, Seyed Mohammad Ali Hajghani, Masomeh Khodadadi, Hassan Pourali, Reza Arababadi, Mohammad Kazemi Kennedy, Derek |
| description | Studies indicated that CC receptor 5 (CCR5), as a receptor for CC ligand 3, CCL4, and CCL5, plays important roles in the recruitment of T cytotoxic lymphocytes to the liver of chronic HBV (CHB)-infected patients. The main purpose of this study was to investigate the expression levels of CCR5 on the CD8
+
T lymphocytes of CHB patients. This clinical study was performed on 63 CHB patients and 96 healthy controls. Flow cytometric analysis was performed to examine the expression of CCR5 on CD8
+
T cells of CHB patients. Real-time PCR was also used for HBV-DNA quantification. The results of our study demonstrated that CCR5 expressing T cytotoxic cells were decreased significantly in CHB patients in comparison to healthy control. Based on our results, it can be concluded that the percent of CCR5
+
/CD8
+
T cells in Iranian CHB patients is significantly decreased, hence their migration to the infected liver, and HBV eradication from the hepatocytes is disrupted. |
| doi_str_mv | 10.1007/s10753-012-9528-4 |
| format | article |
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+
T lymphocytes of CHB patients. This clinical study was performed on 63 CHB patients and 96 healthy controls. Flow cytometric analysis was performed to examine the expression of CCR5 on CD8
+
T cells of CHB patients. Real-time PCR was also used for HBV-DNA quantification. The results of our study demonstrated that CCR5 expressing T cytotoxic cells were decreased significantly in CHB patients in comparison to healthy control. Based on our results, it can be concluded that the percent of CCR5
+
/CD8
+
T cells in Iranian CHB patients is significantly decreased, hence their migration to the infected liver, and HBV eradication from the hepatocytes is disrupted.</description><identifier>ISSN: 0360-3997</identifier><identifier>EISSN: 1573-2576</identifier><identifier>DOI: 10.1007/s10753-012-9528-4</identifier><identifier>PMID: 22918850</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Alanine Transaminase - blood ; Alkaline Phosphatase - blood ; Aspartate Aminotransferases - blood ; Bilirubin - blood ; Biomedical and Life Sciences ; Biomedicine ; CD8-Positive T-Lymphocytes - immunology ; CD8-Positive T-Lymphocytes - metabolism ; Cell Movement ; DNA, Viral - analysis ; Down-Regulation ; Female ; Gene Expression ; Hepatitis B virus - immunology ; Hepatitis B virus - isolation & purification ; Hepatitis B, Chronic - blood ; Hepatitis B, Chronic - immunology ; Hepatitis B, Chronic - virology ; Humans ; Immunology ; Internal Medicine ; Iran ; Liver - immunology ; Liver - virology ; Liver Function Tests ; Male ; Pathology ; Pharmacology/Toxicology ; Receptors, CCR5 - biosynthesis ; Rheumatology ; T-Lymphocytes, Cytotoxic - immunology ; T-Lymphocytes, Cytotoxic - metabolism</subject><ispartof>Inflammation, 2013-02, Vol.36 (1), p.136-140</ispartof><rights>Springer Science+Business Media, LLC 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-ad19799f10ca42326f2db29e3aef5a87f7008a8dc1d3b358de4590b8d4f04c643</citedby><cites>FETCH-LOGICAL-c344t-ad19799f10ca42326f2db29e3aef5a87f7008a8dc1d3b358de4590b8d4f04c643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22918850$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahmadabadi, Behzad Nasiri</creatorcontrib><creatorcontrib>Hassanshahi, Gholamhossein</creatorcontrib><creatorcontrib>Khoramdelazad, Hossein</creatorcontrib><creatorcontrib>Mirzaei, Vahid</creatorcontrib><creatorcontrib>Sajadi, Seyed Mohammad Ali</creatorcontrib><creatorcontrib>Hajghani, Masomeh</creatorcontrib><creatorcontrib>Khodadadi, Hassan</creatorcontrib><creatorcontrib>Pourali, Reza</creatorcontrib><creatorcontrib>Arababadi, Mohammad Kazemi</creatorcontrib><creatorcontrib>Kennedy, Derek</creatorcontrib><title>Downregulation of CCR5 Expression on the Peripheral Blood CD8+ T Cells of Southeastern Iranian Patients with Chronic Hepatitis B Infection</title><title>Inflammation</title><addtitle>Inflammation</addtitle><addtitle>Inflammation</addtitle><description>Studies indicated that CC receptor 5 (CCR5), as a receptor for CC ligand 3, CCL4, and CCL5, plays important roles in the recruitment of T cytotoxic lymphocytes to the liver of chronic HBV (CHB)-infected patients. The main purpose of this study was to investigate the expression levels of CCR5 on the CD8
+
T lymphocytes of CHB patients. This clinical study was performed on 63 CHB patients and 96 healthy controls. Flow cytometric analysis was performed to examine the expression of CCR5 on CD8
+
T cells of CHB patients. Real-time PCR was also used for HBV-DNA quantification. The results of our study demonstrated that CCR5 expressing T cytotoxic cells were decreased significantly in CHB patients in comparison to healthy control. Based on our results, it can be concluded that the percent of CCR5
+
/CD8
+
T cells in Iranian CHB patients is significantly decreased, hence their migration to the infected liver, and HBV eradication from the hepatocytes is disrupted.</description><subject>Adult</subject><subject>Alanine Transaminase - blood</subject><subject>Alkaline Phosphatase - blood</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Bilirubin - blood</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>CD8-Positive T-Lymphocytes - metabolism</subject><subject>Cell Movement</subject><subject>DNA, Viral - analysis</subject><subject>Down-Regulation</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Hepatitis B virus - immunology</subject><subject>Hepatitis B virus - isolation & purification</subject><subject>Hepatitis B, Chronic - blood</subject><subject>Hepatitis B, Chronic - immunology</subject><subject>Hepatitis B, Chronic - virology</subject><subject>Humans</subject><subject>Immunology</subject><subject>Internal Medicine</subject><subject>Iran</subject><subject>Liver - immunology</subject><subject>Liver - virology</subject><subject>Liver Function Tests</subject><subject>Male</subject><subject>Pathology</subject><subject>Pharmacology/Toxicology</subject><subject>Receptors, CCR5 - biosynthesis</subject><subject>Rheumatology</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><subject>T-Lymphocytes, Cytotoxic - metabolism</subject><issn>0360-3997</issn><issn>1573-2576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9kc9O3DAQxq0KVLbbPkAvlY9IKOA_8do-liztroTEitKz5U3GbFDWTu1EtK_AU9dhgSOnkWa--Y2--RD6Ssk5JUReJEqk4AWhrNCCqaL8gGZUSF4wIRdHaEb4ghRca3mCPqX0QAhRWvGP6IQxTZUSZIaeluHRR7gfOzu0wePgcFXdCnz1t4-Q0nPL42EHeAOx7XcQbYcvuxAaXC3VGb7DFXRdmvZ-hTHrbBogeryO1rfW403Ggh8SfmyHHa52Mfi2xivoc39oE77Ea--gnm5_RsfOdgm-vNQ5-v3j6q5aFdc3P9fV9-ui5mU5FLahWmrtKKltyThbONZsmQZuwQmrpJPZplVNTRu-5UI1UApNtqopHSnrRcnn6PTA7WP4M0IazL5NdXZhPYQxGcokl1qI_Mg5ogdpHUNKEZzpY7u38Z-hxEwRmEMEJkdgpgjMhP_2gh-3e2jeNl5_ngXsIEh55O8hmocwRp8tv0P9D_hkkf0</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Ahmadabadi, Behzad Nasiri</creator><creator>Hassanshahi, Gholamhossein</creator><creator>Khoramdelazad, Hossein</creator><creator>Mirzaei, Vahid</creator><creator>Sajadi, Seyed Mohammad Ali</creator><creator>Hajghani, Masomeh</creator><creator>Khodadadi, Hassan</creator><creator>Pourali, Reza</creator><creator>Arababadi, Mohammad Kazemi</creator><creator>Kennedy, Derek</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130201</creationdate><title>Downregulation of CCR5 Expression on the Peripheral Blood CD8+ T Cells of Southeastern Iranian Patients with Chronic Hepatitis B Infection</title><author>Ahmadabadi, Behzad Nasiri ; Hassanshahi, Gholamhossein ; Khoramdelazad, Hossein ; Mirzaei, Vahid ; Sajadi, Seyed Mohammad Ali ; Hajghani, Masomeh ; Khodadadi, Hassan ; Pourali, Reza ; Arababadi, Mohammad Kazemi ; Kennedy, Derek</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-ad19799f10ca42326f2db29e3aef5a87f7008a8dc1d3b358de4590b8d4f04c643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Alanine Transaminase - blood</topic><topic>Alkaline Phosphatase - blood</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Bilirubin - blood</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>CD8-Positive T-Lymphocytes - metabolism</topic><topic>Cell Movement</topic><topic>DNA, Viral - analysis</topic><topic>Down-Regulation</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Hepatitis B virus - immunology</topic><topic>Hepatitis B virus - isolation & purification</topic><topic>Hepatitis B, Chronic - blood</topic><topic>Hepatitis B, Chronic - immunology</topic><topic>Hepatitis B, Chronic - virology</topic><topic>Humans</topic><topic>Immunology</topic><topic>Internal Medicine</topic><topic>Iran</topic><topic>Liver - immunology</topic><topic>Liver - virology</topic><topic>Liver Function Tests</topic><topic>Male</topic><topic>Pathology</topic><topic>Pharmacology/Toxicology</topic><topic>Receptors, CCR5 - biosynthesis</topic><topic>Rheumatology</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><topic>T-Lymphocytes, Cytotoxic - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahmadabadi, Behzad Nasiri</creatorcontrib><creatorcontrib>Hassanshahi, Gholamhossein</creatorcontrib><creatorcontrib>Khoramdelazad, Hossein</creatorcontrib><creatorcontrib>Mirzaei, Vahid</creatorcontrib><creatorcontrib>Sajadi, Seyed Mohammad Ali</creatorcontrib><creatorcontrib>Hajghani, Masomeh</creatorcontrib><creatorcontrib>Khodadadi, Hassan</creatorcontrib><creatorcontrib>Pourali, Reza</creatorcontrib><creatorcontrib>Arababadi, Mohammad Kazemi</creatorcontrib><creatorcontrib>Kennedy, Derek</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahmadabadi, Behzad Nasiri</au><au>Hassanshahi, Gholamhossein</au><au>Khoramdelazad, Hossein</au><au>Mirzaei, Vahid</au><au>Sajadi, Seyed Mohammad Ali</au><au>Hajghani, Masomeh</au><au>Khodadadi, Hassan</au><au>Pourali, Reza</au><au>Arababadi, Mohammad Kazemi</au><au>Kennedy, Derek</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Downregulation of CCR5 Expression on the Peripheral Blood CD8+ T Cells of Southeastern Iranian Patients with Chronic Hepatitis B Infection</atitle><jtitle>Inflammation</jtitle><stitle>Inflammation</stitle><addtitle>Inflammation</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>36</volume><issue>1</issue><spage>136</spage><epage>140</epage><pages>136-140</pages><issn>0360-3997</issn><eissn>1573-2576</eissn><abstract>Studies indicated that CC receptor 5 (CCR5), as a receptor for CC ligand 3, CCL4, and CCL5, plays important roles in the recruitment of T cytotoxic lymphocytes to the liver of chronic HBV (CHB)-infected patients. The main purpose of this study was to investigate the expression levels of CCR5 on the CD8
+
T lymphocytes of CHB patients. This clinical study was performed on 63 CHB patients and 96 healthy controls. Flow cytometric analysis was performed to examine the expression of CCR5 on CD8
+
T cells of CHB patients. Real-time PCR was also used for HBV-DNA quantification. The results of our study demonstrated that CCR5 expressing T cytotoxic cells were decreased significantly in CHB patients in comparison to healthy control. Based on our results, it can be concluded that the percent of CCR5
+
/CD8
+
T cells in Iranian CHB patients is significantly decreased, hence their migration to the infected liver, and HBV eradication from the hepatocytes is disrupted.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>22918850</pmid><doi>10.1007/s10753-012-9528-4</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0360-3997 |
| ispartof | Inflammation, 2013-02, Vol.36 (1), p.136-140 |
| issn | 0360-3997 1573-2576 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1273795557 |
| source | Springer Nature |
| subjects | Adult Alanine Transaminase - blood Alkaline Phosphatase - blood Aspartate Aminotransferases - blood Bilirubin - blood Biomedical and Life Sciences Biomedicine CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Movement DNA, Viral - analysis Down-Regulation Female Gene Expression Hepatitis B virus - immunology Hepatitis B virus - isolation & purification Hepatitis B, Chronic - blood Hepatitis B, Chronic - immunology Hepatitis B, Chronic - virology Humans Immunology Internal Medicine Iran Liver - immunology Liver - virology Liver Function Tests Male Pathology Pharmacology/Toxicology Receptors, CCR5 - biosynthesis Rheumatology T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism |
| title | Downregulation of CCR5 Expression on the Peripheral Blood CD8+ T Cells of Southeastern Iranian Patients with Chronic Hepatitis B Infection |
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