Prevalence, risk factors, and consequences of overweight in children and adolescents who underwent renal transplantation - Short- and medium-term analysis

To determine the prevalence and risk factors for (i) overweight/obesity and (ii) weight gain six months after transplantation and to study the effect of weight excess on graft function and survival. We performed a retrospective study of kidney transplanted children. Endpoints: (i) prevalence of over...

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Bibliographic Details
Published in:Pediatric transplantation 2013-02, Vol.17 (1), p.41-47
Main Authors: Boschetti, Sofia Bonna, Nogueira, Paulo Cesar Koch, Pereira, Aline Maria Luiz, Fisberg, Mauro, Pestana, José Osmar Medina
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
Body Mass Index
Child
Child, Preschool
Epidemiology
Female
General aspects
Glomerular Filtration Rate
Graft Survival
Humans
kidney transplantation
Kidney Transplantation - adverse effects
Kidney Transplantation - methods
Living Donors
Male
Medical sciences
Metabolic diseases
Obesity
Obesity - epidemiology
Obesity - etiology
Overweight - epidemiology
Overweight - etiology
Public health. Hygiene
Public health. Hygiene-occupational medicine
Renal Insufficiency - surgery
Retrospective Studies
Risk Factors
Steroids - therapeutic use
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
Treatment Outcome
Weight Gain
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Summary:To determine the prevalence and risk factors for (i) overweight/obesity and (ii) weight gain six months after transplantation and to study the effect of weight excess on graft function and survival. We performed a retrospective study of kidney transplanted children. Endpoints: (i) prevalence of overweight/obesity at sixth month, (ii) gaining 1.0 BMI SDS from one to six months. To study the effects of weight excess, graft function and survival at 36 months were the endpoints. The study included 197 individuals. At sixth month, 57/197 (29%) presented overweight/obesity, and the factors associated to this outcome were: (i) age at transplantation (OR = 3.04) and (ii) overweight/obesity in the first month (OR = 22.16). Groups presented no difference on graft function and survival at 36 months. From one to six months, 90/197 (46%) patients gained >1.0 BMI SDS. This outcome was associated with (i) female sex (OR = 2.50), (ii) steroids' pulses (OR = 2.98), (iii) steroids exposure (OR = 1.04), and (iv) living donor (OR = 2.69). The group that gained BMI presented a lower 36 months graft survival (86% vs. 98%, p 
ISSN:1397-3142
1399-3046
DOI:10.1111/petr.12020