Formulation and optimization of desogestrel transdermal contraceptive patch using crystallization studies

Levonorgestrel (LNG) is the most commonly used progestin in contraception. In this study, we report the use of an alternative progestin, desogestrel, for transdermal contraception. The drug was found to be significantly more permeable as compared to LNG (p

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Bibliographic Details
Published in:International journal of pharmaceutics 2013-01, Vol.441 (1-2), p.9-18
Main Authors: Sachdeva, Vishal, Bai, Yun, Kydonieus, Agis, Banga, Ajay K.
Format: Article
Language:English
Subjects:
Acrylate adhesive
adhesion
adhesives
Adhesives - chemistry
Animals
contraception
Contraceptive
Contraceptives, Oral, Synthetic - administration & dosage
Contraceptives, Oral, Synthetic - pharmacokinetics
cosmetics
Crystallization
Desogestrel
Desogestrel - administration & dosage
Desogestrel - pharmacokinetics
drugs
Excipients - chemistry
Levonorgestrel - administration & dosage
Levonorgestrel - pharmacokinetics
Male
mineral oil
Mineral Oil - chemistry
Polyisobutylene adhesive
Pyrrolidines - chemistry
Rats
Rats, Hairless
Reproducibility of Results
rolling
Skin Absorption
Solubility
Transdermal Patch
Vinyl Compounds - chemistry
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Description
Summary:Levonorgestrel (LNG) is the most commonly used progestin in contraception. In this study, we report the use of an alternative progestin, desogestrel, for transdermal contraception. The drug was found to be significantly more permeable as compared to LNG (p
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2012.12.014