Fabrication, characterization and in vitro profile based interaction with eukaryotic and prokaryotic cells of alginate–chitosan–silica biocomposite

This work is focused on the fabrication of a new drug delivery system based on polyanionic matrix (e.g. sodium alginate), polycationic matrix (e.g. chitosan) and silica network. The FT-IR, SEM, DTA-TG, eukaryotic cell cycle and viability, and in vitro assay of the influence of the biocomposite on th...

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Bibliographic Details
Published in:International journal of pharmaceutics 2013-01, Vol.441 (1-2), p.555-561
Main Authors: Balaure, Paul Cǎtǎlin, Andronescu, Ecaterina, Grumezescu, Alexandru Mihai, Ficai, Anton, Huang, Keng-Shiang, Yang, Chih-Hui, Chifiriuc, Carmen Mariana, Lin, Yung-Sheng
Format: Article
Language:English
Subjects:
Alginates - chemistry
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - pharmacology
biocompatibility
Biocomposite
biocomposites
cefazolin
ceftriaxone
cefuroxime
cell cycle
Cell Cycle - drug effects
Cell Survival - drug effects
Chitosan
Chitosan - chemistry
Drug Carriers - chemistry
Drug Delivery Systems
drugs
Escherichia coli
Escherichia coli - drug effects
Eukaryotic cell
eukaryotic cells
Eukaryotic Cells - drug effects
Eukaryotic Cells - metabolism
Fourier transform infrared spectroscopy
gentamicin
Glucuronic Acid - chemistry
Hexuronic Acids - chemistry
imipenem
in vitro studies
Microscopy, Electron, Scanning
piperacillin
Prokaryotic cell
prokaryotic cells
Prokaryotic Cells - drug effects
Prokaryotic Cells - metabolism
Pseudomonas aeruginosa
Pseudomonas aeruginosa - drug effects
scanning electron microscopy
silica
Silica network
Silicon Dioxide - chemistry
Sodium alginate
Spectroscopy, Fourier Transform Infrared
sulfamethoxazole
Thermogravimetry
trimethoprim
viability
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Summary:This work is focused on the fabrication of a new drug delivery system based on polyanionic matrix (e.g. sodium alginate), polycationic matrix (e.g. chitosan) and silica network. The FT-IR, SEM, DTA-TG, eukaryotic cell cycle and viability, and in vitro assay of the influence of the biocomposite on the efficacy of antibiotic drugs were investigated. The obtained results demonstrated the biocompatibility and the ability of the fabricated biocomposite to maintain or improve the efficacy of the following antibiotics: piperacillin-tazobactam, cefepime, piperacillin, imipenem, gentamicin, ceftazidime against Pseudomonas aeruginosa ATCC 27853 and cefazolin, cefaclor, cefuroxime, ceftriaxone, cefoxitin, trimethoprim/sulfamethoxazole against Escherichia coli ATCC 25922 reference strains.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2012.10.045