Altered Sexual and Reproductive Functions in Epileptic Men Taking Carbamazepine

Epileptic men may experience hormonal changes that may alter semen quality and sexual function. Alterations in male sexual and reproductive parameters may also be due to treatment with antiepileptic drugs to control seizures. To evaluate serum hormone concentrations, semen quality, the frequency of...

Full description

Saved in:
Bibliographic Details
Published in:Journal of sexual medicine 2013-02, Vol.10 (2), p.493-499
Main Authors: Reis, Rosana Maria, de Angelo, Alexandre Gonçalves, Sakamoto, Américo Ceiki, Ferriani, Rui Alberto, Lara, Lúcia Alves Silva
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anticonvulsants - adverse effects
Anticonvulsants - therapeutic use
Carbamazepine
Carbamazepine - adverse effects
Carbamazepine - therapeutic use
Cross-Sectional Studies
Epilepsy
Epilepsy, Temporal Lobe - blood
Epilepsy, Temporal Lobe - drug therapy
Erectile Dysfunction
Erectile Dysfunction - blood
Erectile Dysfunction - chemically induced
Erectile Dysfunction - diagnosis
Gonadal Steroid Hormones - blood
Humans
Male
Seizures and Sexual Dysfunction
Semen Analysis
Sexual Behavior - drug effects
Sexual Function
Sexuality
Sperm Motility - drug effects
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Epileptic men may experience hormonal changes that may alter semen quality and sexual function. Alterations in male sexual and reproductive parameters may also be due to treatment with antiepileptic drugs to control seizures. To evaluate serum hormone concentrations, semen quality, the frequency of sexual intercourse (FSI), and erectile function in men with epileptic seizures controlled by carbamazepine (CBZ). The five‐question form of the International Index of Erectile Function (IIEF‐5), and semi‐structured questionnaire. One hundred and eighteen men, aged 18–45 years, were included in this controlled, cross‐sectional study: 63 men taking CBZ (epileptic group) were compared to 55 healthy men (control group). Blood sample was collected to determine hormones concentrations. Erectile function and the frequency of sexual relations were assessed by using questionnaires. Sperm morphology was analyzed by examining the quality of the head, intermediate part and tail of the spermatozoa. Using the IIEF‐5, we observed a significant association between erectile dysfunction (ED) and groups (P 
ISSN:1743-6095
1743-6109
DOI:10.1111/j.1743-6109.2012.02951.x