G6PD deficiency-induced hemolysis in a Chinese diabetic patient: a case report with clinical and molecular analysis

A 59-year-old Chinese male patient was admitted at diagnosis of type1 diabetes with ketoacidosis. During the normalization of blood glucose with insulin, the patient developed acute hemolysis. The factors predisposing to hemolysis were not found, except the significantly diminished activity of gluco...

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Bibliographic Details
Published in:Acta diabetologica 2013-02, Vol.50 (1), p.89-92
Main Authors: Gu, Xue-Jiang, Chen, Shuo-Ping, Ge, Sheng-Jie, Zheng, Le-Qun, Wang, Da-Wang, Shen, Fei-Xia
Format: Article
Language:English
Subjects:
Case Report
China
Diabetes
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - enzymology
Diabetes Mellitus, Type 1 - genetics
Diabetes Mellitus, Type 1 - pathology
Diabetic Ketoacidosis - enzymology
Diabetic Ketoacidosis - etiology
Diabetic Ketoacidosis - genetics
Diabetic Ketoacidosis - pathology
Enzymes
Glucosephosphate Dehydrogenase - genetics
Glucosephosphate Dehydrogenase - metabolism
Glucosephosphate Dehydrogenase Deficiency - complications
Glucosephosphate Dehydrogenase Deficiency - genetics
Glucosephosphate Dehydrogenase Deficiency - metabolism
Glucosephosphate Dehydrogenase Deficiency - pathology
Hemolysis
Humans
Internal Medicine
Male
Medical diagnosis
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Molecular biology
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Description
Summary:A 59-year-old Chinese male patient was admitted at diagnosis of type1 diabetes with ketoacidosis. During the normalization of blood glucose with insulin, the patient developed acute hemolysis. The factors predisposing to hemolysis were not found, except the significantly diminished activity of glucose-6-phosphate dehydrogenase (G6PD). DNA analysis did not show any coding or intronic mutation in the G6PD gene. This is the first reported case of a Chinese patient in diabetic ketoacidosis with hemolysis induced by G6PD deficiency in the absence of mutations in the G6PD gene.
ISSN:0940-5429
1432-5233
DOI:10.1007/s00592-010-0236-y