Reduced seizure threshold and altered network oscillatory properties in a mouse model of Rett syndrome

Highlights ► We show altered seizure threshold in a mouse model of Rett syndrome. ► Network level hyperexcitability is also revealed in brain slices from Rett mice. ► This contrasts with normal intrinsic excitability at the level of single neurons.

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Bibliographic Details
Published in:Neuroscience 2013-02, Vol.231, p.195-205
Main Authors: McLeod, F, Ganley, R, Williams, L, Selfridge, J, Bird, A, Cobb, S.R
Format: Article
Language:English
Subjects:
4-Aminopyridine - pharmacology
Animals
Bicuculline - pharmacology
Biological and medical sciences
Brain Waves - drug effects
Brain Waves - physiology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Disease Models, Animal
epilepsy
excitability
Excitatory Amino Acid Agonists - pharmacology
GABA-A Receptor Antagonists - pharmacology
gamma oscillations
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Hippocampus - drug effects
Hippocampus - physiopathology
Kainic Acid - pharmacology
MECP2
Medical sciences
Methyl-CpG-Binding Protein 2 - genetics
Mice
Nerve Net - drug effects
Nerve Net - physiopathology
Nervous system (semeiology, syndromes)
network
Neurology
Neurons - drug effects
Neurons - physiology
Potassium Channel Blockers - pharmacology
Rett Syndrome
Rett Syndrome - genetics
Rett Syndrome - physiopathology
Seizures - physiopathology
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Description
Summary:Highlights ► We show altered seizure threshold in a mouse model of Rett syndrome. ► Network level hyperexcitability is also revealed in brain slices from Rett mice. ► This contrasts with normal intrinsic excitability at the level of single neurons.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.11.058