Skull-base Ewing sarcoma with multifocal extracranial metastases

Intracranial occurrence of Ewing sarcoma (ES) is unusual, with a skull-base location being anecdotal. We report a 29-year-old man who presented with rapidly progressive ophthalmoplegia, and was found to be harboring an infiltrative lesion involving the sphenoid sinus, sella, and clivus. He underwent...

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Bibliographic Details
Published in:Journal of cancer research and therapeutics 2012, Vol.8 (4), p.636-638
Main Authors: Thakar, Sumit, Furtado, Sunil, Ghosal, Nandita, Dilip, Jethwani, Mahadevan, Anita, Hegde, Alangar
Format: Report
Language:English
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Summary:Intracranial occurrence of Ewing sarcoma (ES) is unusual, with a skull-base location being anecdotal. We report a 29-year-old man who presented with rapidly progressive ophthalmoplegia, and was found to be harboring an infiltrative lesion involving the sphenoid sinus, sella, and clivus. He underwent trans-sphenoidal decompression of the lesion which was histologically suggestive of ES. He developed paraparesis 2 weeks after commencing adjuvant therapy. Imaging revealed two thoracic extradural lesions and florid vertebral and pulmonary metastases. This is the first report in indexed literature of a primary intracranial ES on the skull-base with disseminated extracranial disease.
ISSN:1998-4138
DOI:10.4103/0973-1482.106584