Mechanism of dispersion polymerization of L-lactide initiated with 2,2-dibutyl-2-stanna-1,3-dioxepane

• Published in: Colloid and polymer science 2002-02, Vol.280 (2), p.107-115
• Main Authors: SOSNOWSKI, S, SLOMKOWSKI, S, LORENC, A, KRICHELDORF, H. R
• Format: Article
• Language: English
• Subjects: Applied sciences; Desorption; Dispersions; Exact sciences and technology; Ionization; Ions; Macromolecules; Microspheres; Monomers; Organic polymers; Physicochemistry of polymers; Polymerization; Preparation, kinetics, thermodynamics, mechanism and catalysts; Propagation (polymerization); Transesterification
• ISSN: 0303-402X; 1435-1536
• DOI: 10.1007/s003960100564

Biodegradable polyester microspheres were synthesized directly by ring-opening polymerization of l-lactide initiated with 2,2-dibutyl-2-stanna-1,3-dioxepane. The polymerizations were carried out at 95 °C in a mixture of organic solvents (heptane/1,4-dioxane 4:1 v:v), in the presence of poly(dodecyl acrylate)-g-poly(-caprolactone) used as a surface-active agent. Under these conditions the poly(L-lactide) synthesized was shaped into microspheres. The absence of new particles in the polymerizations with multistep monomer addition indicated that after the formation of particle seeds the propagation proceeds exclusively inside the microspheres. The mean volume of these microspheres was proportional to the monomer conversion. It was found that regardless of the initiator concentration the average number of poly(L-lactide) macromolecules in one microsphere was 1.84 × 10^sup 8^. Matrix-assisted laser desorption ionization time of flight spectroscopy of poly(L-lactide) in the microspheres indicated that the propagation in the particles was accompanied by intra- and intermolecular transesterification side reactions, resulting in reshuffling of the polymer segments and the formation of cyclic oligomers.[PUBLICATION ABSTRACT]