The use of sodium hyaluronate-carboxymethylcellulose to prevent postoperative mastication pain from harvesting of temporalis fascia

Abstract Objective To evaluate the anti-adhesive and anti-inflammatory effects of sodium hyaluronate-carboxymethylcellulose (HA-CMC) in reducing postoperative pain after temporalis fascia harvest during tympanomastoid surgery. Materials and methods Between January and December 2009, 27 patients unde...

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Bibliographic Details
Published in:Auris, nasus, larynx nasus, larynx, 2013-02, Vol.40 (1), p.7-10
Main Authors: Ahn, Joong Ho, Shim, Myung Joo
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis of Variance
Carboxymethylcellulose Sodium - therapeutic use
Drug Carriers
Fascia
Fascia - transplantation
Female
Humans
Hyaluronic acid
Hyaluronic Acid - therapeutic use
Male
Mastication
Mastoid - surgery
Middle Aged
Otolaryngology
Pain Measurement
Pain, Postoperative - etiology
Pain, Postoperative - prevention & control
Postoperative pain
Prospective Studies
Single-Blind Method
Temporal muscle
Tissue Adhesions - prevention & control
Transplant Donor Site
Tympanoplasty
Viscosupplements - therapeutic use
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Summary:Abstract Objective To evaluate the anti-adhesive and anti-inflammatory effects of sodium hyaluronate-carboxymethylcellulose (HA-CMC) in reducing postoperative pain after temporalis fascia harvest during tympanomastoid surgery. Materials and methods Between January and December 2009, 27 patients underwent tympanoplasty and open cavity mastoidectomy involving the harvesting of temporalis fasciae (more than 3 × 4 cm). At the end of surgery, patients were injected with 1.5 g HA-CMC or normal saline around the fascia harvest area. Beginning immediately postoperatively and for 2 months after surgery, patients scored their pain in the temporal area on a visual analogue scale (VAS). Results There were no significant postoperative complications, such as bleeding or hematoma, in either control group. VAS scores of both groups decreased over time and were negligible after 2 months. VAS scores of the HA-CMC and control groups differed significantly ( p < 0.001 by repeated measures ANOVA for all VAS scores). Conclusion HA-CMC can decrease immediate postoperative pain arising from tissue adhesion and inflammation, thus reducing postoperative mastication pain.
ISSN:0385-8146
1879-1476
DOI:10.1016/j.anl.2011.12.002