Influence of ionotropic receptor location on their dynamics at glutamatergic synapses

In this paper we study the effects of the location of ionotropic receptors, especially AMPA and NMDA receptors, on their function at excitatory glutamatergic synapses. As few computational models only allow to evaluate the influence of receptor location on state transition and receptor dynamics, we...

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Bibliographic Details
Main Authors: Allam, Sushmita L., Bouteiller, J. C., Hu, Eric Y., Greget, R., Ambert, N., Bischoff, S., Baudry, M., Berger, T. W.
Format: Conference Proceeding
Language:English
Subjects:
Biomedical engineering
Computational modeling
Educational institutions
Electronic mail
Hidden Markov models
Kinetic theory
Neurotransmitters
Online Access:Request full text
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Summary:In this paper we study the effects of the location of ionotropic receptors, especially AMPA and NMDA receptors, on their function at excitatory glutamatergic synapses. As few computational models only allow to evaluate the influence of receptor location on state transition and receptor dynamics, we present an elaborate computational model of a glutamatergic synapse that takes into account detailed parametric models of ionotropic receptors along with glutamate diffusion within the synaptic cleft. Our simulation results underscore the importance of the wide spread distribution of AMPA receptors which is required to avoid massive desensitization of these receptors following a single glutamate release event while NMDA receptor location is potentially optimal relative to the glutamate release site thus, emphasizing the contribution of location dependent effects of the two major ionotropic receptors to synaptic efficacy.
ISSN:1094-687X
1558-4615
2694-0604
DOI:10.1109/EMBC.2012.6346194