Association of stromal-derived factor-1 alpha and endogenous sex hormones in men aged over 50 years with stable coronary artery disease

Many studies indicate an inverse relationship between stromal-derived factor-1 alpha (SDF-1 alpha), a chemokine, and coronary risk factors. Moreover, SDF-1 alpha is crucial in neoangiogenesis and in the mobilization and homing of endothelial progenitor cells to the ischemic coronary vessels. Numerou...

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Bibliographic Details
Published in:Advances in medical sciences 2012-12, Vol.57 (2), p.322-327
Main Authors: Barud, W, Nasiłowska-Barud, A, Sobstyl, J, Mieczkowska, J, Wójcicka, G, Bełtowski, J, Myśliński, W, Mosiewicz, J
Format: Article
Language:English
Subjects:
Aged
Chemokine CXCL12 - blood
coronary artery disease
Coronary Artery Disease - blood
Cross-Sectional Studies
Estradiol - blood
Gonadal Steroid Hormones - blood
Humans
Male
men
Middle Aged
Risk Factors
SDF-1 alpha
Sex Hormone-Binding Globulin - metabolism
sex hormones
Testosterone - blood
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Summary:Many studies indicate an inverse relationship between stromal-derived factor-1 alpha (SDF-1 alpha), a chemokine, and coronary risk factors. Moreover, SDF-1 alpha is crucial in neoangiogenesis and in the mobilization and homing of endothelial progenitor cells to the ischemic coronary vessels. Numerous studies indicate that circulating sex hormones are associated with atherogenesis during male aging. The aim of this study was therefore to determine whether there exists a relationship between SDF-1 alpha and endogenous sex hormones in aging men with stable coronary artery disease (CAD). Plasma concentrations of SDF-1 alpha, testosterone (T), estradiol (E2), and sex hormone binding globulin (SHBG) were measured and the E2/T ratio was calculated in a cross-sectional study of 82 men over 50 years of age with stable CAD. SDF-1 alpha was positively and significantly correlated with T (r = 0.233; p = 0.036) and with SHBG (r = 0.312; p = 0.004). There was a significant inverse correlation between SDF-1 alpha and the E2/T ratio (r = -0.463; p < 0.001). After adjustment for age, body mass index and smoking status, SHBG and E2/T ratio were the only factors associated with SDF-1 alpha. T and SHBG (directly) and the E2/T ratio (inversely) may be involved in the etiopathogenesis of CAD through their relationships to SDF-1 alpha.
ISSN:1896-1126
1898-4002
DOI:10.2478/v10039-012-0051-5