Direct Lactonization of 2‑Arylacetic Acids through Pd(II)-Catalyzed C–H Activation/C–O Formation

Palladium-catalyzed direct lactonization of 2-arylacetic acids through a reaction sequence that includes C–H activation/C–O formation is reported. This method provides a concise and efficient pathway to synthesize fully functionalized benzofuranone derivatives, which are highly relevant to bioactive...

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Bibliographic Details
Published in:Organic letters 2013-02, Vol.15 (3), p.690-693
Main Authors: Yang, Mingyu, Jiang, Xingyu, Shi, Wen-Juan, Zhu, Qi-Lei, Shi, Zhang-Jie
Format: Article
Language:English
Subjects:
Acetates - chemistry
Benzofurans - chemical synthesis
Benzofurans - chemistry
Carboxylic Acids - chemistry
Catalysis
Molecular Structure
Palladium - chemistry
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Summary:Palladium-catalyzed direct lactonization of 2-arylacetic acids through a reaction sequence that includes C–H activation/C–O formation is reported. This method provides a concise and efficient pathway to synthesize fully functionalized benzofuranone derivatives, which are highly relevant to bioactive natural and synthetic products.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol303569b