Efficacy of hypofractionated radiotherapy for nasal tumours in 38 dogs (2005-2008)

Objectives To evaluate the efficacy of hypofractionated radiotherapy for canine nasal tumours, including the improvement in clinical signs, rate of complications and assessment of prognostic factors. Methods Medical records of 38 dogs with malignant nasal tumours were reviewed, and those treated wit...

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Bibliographic Details
Published in:Journal of small animal practice 2013-02, Vol.54 (2), p.80-86
Main Authors: Fujiwara, A., Kobayashi, T., Kazato, Y., Yayoshi, N., Fujita, M.
Format: Article
Language:English
Subjects:
Age Factors
Animals
Breeding
Disease-Free Survival
Dog Diseases - mortality
Dog Diseases - radiotherapy
Dogs
Dose Fractionation
Dose-Response Relationship, Radiation
Drug therapy
Female
Kaplan-Meier Estimate
Male
Nose Neoplasms - mortality
Nose Neoplasms - radiotherapy
Nose Neoplasms - veterinary
Proportional Hazards Models
Radiation therapy
Radiotherapy - adverse effects
Radiotherapy - veterinary
Studies
Treatment Outcome
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Summary:Objectives To evaluate the efficacy of hypofractionated radiotherapy for canine nasal tumours, including the improvement in clinical signs, rate of complications and assessment of prognostic factors. Methods Medical records of 38 dogs with malignant nasal tumours were reviewed, and those treated with a weekly schedule of hypofractionated radiotherapy were included in the study. Acute and late side effects were defined as complications noted either within 1 month or after 6 months of irradiation, respectively. Progression‐free interval and overall survival were calculated using the Kaplan–Meier method. Log‐rank test and Cox proportional hazard model were also performed. Results Clinical signs improved in 30 of 36 dogs. Acute complications were seen in 28 of 36 dogs and were considered manageable. Late complications were observed in 17 of 30 dogs that survived 6 months or longer, but severe side effects were not observed. The median progression‐free interval and overall survival was 245 days (95% CI: 127–512 days) and 512 days (95% CI: 203–820 days), respectively. Age, breed and presence of dyspnoea were negatively correlated with overall survival. Clinical Significance These results suggest that hypofractionated radiotherapy could be a viable option for the treatment of nasal tumours in dogs that are not candidates for conventional multi‐fractionated radiotherapy.
ISSN:0022-4510
1748-5827
DOI:10.1111/jsap.12024