Interleukin-12 Is Associated With Arterial Stiffness in Healthy Individuals

BACKGROUND Atherosclerotic cardiovascular disease (CVD) is a chronic inflammatory disease mediated by the proinflammatory cytokines interleukin-12 (IL-12) and interleukin-18 (IL-18). Evidence suggests that IL-12 is dominant in early atherosclerosis, while IL-18 is critical in advanced atherosclerosi...

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Published in:American journal of hypertension 2013-02, Vol.26 (2), p.159-162
Main Authors: Yong, Kenneth, Dogra, Gursharan, Boudville, Neil, Chan, Doris, Adams, Leon, Ching, Helena, Lim, Ee M., Lim, Wai H.
Format: Article
Language:English
Subjects:
Adult
Atherosclerosis
Atherosclerosis - epidemiology
Atherosclerosis - physiopathology
Biomarkers - blood
Cholesterol
Cross-Sectional Studies
Cytokines
Female
Humans
Interleukin-12 - blood
Interleukin-12 - physiology
Interleukin-18 - blood
Interleukin-18 - physiology
Male
Medical research
Middle Aged
Pulse Wave Analysis
Regression Analysis
Risk Factors
Vascular Stiffness - physiology
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Summary:BACKGROUND Atherosclerotic cardiovascular disease (CVD) is a chronic inflammatory disease mediated by the proinflammatory cytokines interleukin-12 (IL-12) and interleukin-18 (IL-18). Evidence suggests that IL-12 is dominant in early atherosclerosis, while IL-18 is critical in advanced atherosclerosis. In this study, we explore the association between IL-12 and IL-18 and arterial stiffness in healthy individuals. METHODS We performed a cross-sectional study examining pulse wave velocity (PWV), augmentation index (AIx), IL-12, and IL-18 in healthy individuals (N = 53) without CVD risk factors. RESULTS In multivariate regression, age (P < 0.01), systolic blood pressure (P = 0.05), and IL-12 (P < 0.01) were positively associated with PWV, and high-density lipoprotein (P = 0.04) was negatively associated with PWV (model R 2 = 0.476, P < 0.01). CONCLUSIONS IL-12, but not IL-18, is associated with PWV in healthy individuals without clinical CVD, supporting a role for IL-12 in early atherosclerosis as suggested by animal studies.
ISSN:0895-7061
1941-7225
DOI:10.1093/ajh/hps032