Loading…
Interleukin-12 Is Associated With Arterial Stiffness in Healthy Individuals
BACKGROUND Atherosclerotic cardiovascular disease (CVD) is a chronic inflammatory disease mediated by the proinflammatory cytokines interleukin-12 (IL-12) and interleukin-18 (IL-18). Evidence suggests that IL-12 is dominant in early atherosclerosis, while IL-18 is critical in advanced atherosclerosi...
Saved in:
| Published in: | American journal of hypertension 2013-02, Vol.26 (2), p.159-162 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c381t-17abbe6b2510abd4f6c983c8e171634066a26373406402f121734056dd1a342f3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c381t-17abbe6b2510abd4f6c983c8e171634066a26373406402f121734056dd1a342f3 |
| container_end_page | 162 |
| container_issue | 2 |
| container_start_page | 159 |
| container_title | American journal of hypertension |
| container_volume | 26 |
| creator | Yong, Kenneth Dogra, Gursharan Boudville, Neil Chan, Doris Adams, Leon Ching, Helena Lim, Ee M. Lim, Wai H. |
| description | BACKGROUND
Atherosclerotic cardiovascular disease (CVD) is a chronic inflammatory disease mediated by the proinflammatory cytokines interleukin-12 (IL-12) and interleukin-18 (IL-18). Evidence suggests that IL-12 is dominant in early atherosclerosis, while IL-18 is critical in advanced atherosclerosis. In this study, we explore the association between IL-12 and IL-18 and arterial stiffness in healthy individuals.
METHODS
We performed a cross-sectional study examining pulse wave velocity (PWV), augmentation index (AIx), IL-12, and IL-18 in healthy individuals (N = 53) without CVD risk factors.
RESULTS
In multivariate regression, age (P < 0.01), systolic blood pressure (P = 0.05), and IL-12 (P < 0.01) were positively associated with PWV, and high-density lipoprotein (P = 0.04) was negatively associated with PWV (model R
2 = 0.476, P < 0.01).
CONCLUSIONS
IL-12, but not IL-18, is associated with PWV in healthy individuals without clinical CVD, supporting a role for IL-12 in early atherosclerosis as suggested by animal studies. |
| doi_str_mv | 10.1093/ajh/hps032 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1284622436</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/ajh/hps032</oup_id><sourcerecordid>1284622436</sourcerecordid><originalsourceid>FETCH-LOGICAL-c381t-17abbe6b2510abd4f6c983c8e171634066a26373406402f121734056dd1a342f3</originalsourceid><addsrcrecordid>eNp90E9LwzAYBvAgipvTix9AAiKIUJc3SdP2OIZ_igMPKh5D2qY0s2tr0gr79mZ0evDg6X0OPx5eHoTOgdwCSdhcrat51TnC6AGaQsIhiCgND9GUxEkYRETABJ04tyaEcCHgGE0oYzFlSTJFT2nTa1vr4cM0AVCcOrxwrs2N6nWB301f4YX1wqgav_SmLBvtHDYNftSq7qstTpvCfJliULU7RUelP_psf2fo7f7udfkYrJ4f0uViFeQshj6ASGWZFhkNgais4KXIk5jlsYYIBONECEUFi3aJE1oChV0ORVGAYpyWbIaux97Otp-Ddr3cGJfrulaNbgcngcZcUMqZ8PTyD123g238dxIEQBgzYNSrm1HltnXO6lJ21myU3Uogcjex9BPLcWKPL_aVQ7bRxS_92dSDqxG0Q_df0Te4IoF5</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1611583132</pqid></control><display><type>article</type><title>Interleukin-12 Is Associated With Arterial Stiffness in Healthy Individuals</title><source>Oxford University Press:Jisc Collections:OUP Read and Publish 2024-2025 (2024 collection) (Reading list)</source><creator>Yong, Kenneth ; Dogra, Gursharan ; Boudville, Neil ; Chan, Doris ; Adams, Leon ; Ching, Helena ; Lim, Ee M. ; Lim, Wai H.</creator><creatorcontrib>Yong, Kenneth ; Dogra, Gursharan ; Boudville, Neil ; Chan, Doris ; Adams, Leon ; Ching, Helena ; Lim, Ee M. ; Lim, Wai H.</creatorcontrib><description>BACKGROUND
Atherosclerotic cardiovascular disease (CVD) is a chronic inflammatory disease mediated by the proinflammatory cytokines interleukin-12 (IL-12) and interleukin-18 (IL-18). Evidence suggests that IL-12 is dominant in early atherosclerosis, while IL-18 is critical in advanced atherosclerosis. In this study, we explore the association between IL-12 and IL-18 and arterial stiffness in healthy individuals.
METHODS
We performed a cross-sectional study examining pulse wave velocity (PWV), augmentation index (AIx), IL-12, and IL-18 in healthy individuals (N = 53) without CVD risk factors.
RESULTS
In multivariate regression, age (P < 0.01), systolic blood pressure (P = 0.05), and IL-12 (P < 0.01) were positively associated with PWV, and high-density lipoprotein (P = 0.04) was negatively associated with PWV (model R
2 = 0.476, P < 0.01).
CONCLUSIONS
IL-12, but not IL-18, is associated with PWV in healthy individuals without clinical CVD, supporting a role for IL-12 in early atherosclerosis as suggested by animal studies.</description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1941-7225</identifier><identifier>DOI: 10.1093/ajh/hps032</identifier><identifier>PMID: 23382399</identifier><identifier>CODEN: AJHYE6</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Adult ; Atherosclerosis ; Atherosclerosis - epidemiology ; Atherosclerosis - physiopathology ; Biomarkers - blood ; Cholesterol ; Cross-Sectional Studies ; Cytokines ; Female ; Humans ; Interleukin-12 - blood ; Interleukin-12 - physiology ; Interleukin-18 - blood ; Interleukin-18 - physiology ; Male ; Medical research ; Middle Aged ; Pulse Wave Analysis ; Regression Analysis ; Risk Factors ; Vascular Stiffness - physiology</subject><ispartof>American journal of hypertension, 2013-02, Vol.26 (2), p.159-162</ispartof><rights>American Journal of Hypertension, Ltd 2012. All rights reserved. For Permissions, please email: journals.permissions@oup.com 2012</rights><rights>American Journal of Hypertension, Ltd 2012. All rights reserved. For Permissions, please email: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-17abbe6b2510abd4f6c983c8e171634066a26373406402f121734056dd1a342f3</citedby><cites>FETCH-LOGICAL-c381t-17abbe6b2510abd4f6c983c8e171634066a26373406402f121734056dd1a342f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23382399$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yong, Kenneth</creatorcontrib><creatorcontrib>Dogra, Gursharan</creatorcontrib><creatorcontrib>Boudville, Neil</creatorcontrib><creatorcontrib>Chan, Doris</creatorcontrib><creatorcontrib>Adams, Leon</creatorcontrib><creatorcontrib>Ching, Helena</creatorcontrib><creatorcontrib>Lim, Ee M.</creatorcontrib><creatorcontrib>Lim, Wai H.</creatorcontrib><title>Interleukin-12 Is Associated With Arterial Stiffness in Healthy Individuals</title><title>American journal of hypertension</title><addtitle>AJHYPE</addtitle><addtitle>Am J Hypertens</addtitle><description>BACKGROUND
Atherosclerotic cardiovascular disease (CVD) is a chronic inflammatory disease mediated by the proinflammatory cytokines interleukin-12 (IL-12) and interleukin-18 (IL-18). Evidence suggests that IL-12 is dominant in early atherosclerosis, while IL-18 is critical in advanced atherosclerosis. In this study, we explore the association between IL-12 and IL-18 and arterial stiffness in healthy individuals.
METHODS
We performed a cross-sectional study examining pulse wave velocity (PWV), augmentation index (AIx), IL-12, and IL-18 in healthy individuals (N = 53) without CVD risk factors.
RESULTS
In multivariate regression, age (P < 0.01), systolic blood pressure (P = 0.05), and IL-12 (P < 0.01) were positively associated with PWV, and high-density lipoprotein (P = 0.04) was negatively associated with PWV (model R
2 = 0.476, P < 0.01).
CONCLUSIONS
IL-12, but not IL-18, is associated with PWV in healthy individuals without clinical CVD, supporting a role for IL-12 in early atherosclerosis as suggested by animal studies.</description><subject>Adult</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - epidemiology</subject><subject>Atherosclerosis - physiopathology</subject><subject>Biomarkers - blood</subject><subject>Cholesterol</subject><subject>Cross-Sectional Studies</subject><subject>Cytokines</subject><subject>Female</subject><subject>Humans</subject><subject>Interleukin-12 - blood</subject><subject>Interleukin-12 - physiology</subject><subject>Interleukin-18 - blood</subject><subject>Interleukin-18 - physiology</subject><subject>Male</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>Pulse Wave Analysis</subject><subject>Regression Analysis</subject><subject>Risk Factors</subject><subject>Vascular Stiffness - physiology</subject><issn>0895-7061</issn><issn>1941-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp90E9LwzAYBvAgipvTix9AAiKIUJc3SdP2OIZ_igMPKh5D2qY0s2tr0gr79mZ0evDg6X0OPx5eHoTOgdwCSdhcrat51TnC6AGaQsIhiCgND9GUxEkYRETABJ04tyaEcCHgGE0oYzFlSTJFT2nTa1vr4cM0AVCcOrxwrs2N6nWB301f4YX1wqgav_SmLBvtHDYNftSq7qstTpvCfJliULU7RUelP_psf2fo7f7udfkYrJ4f0uViFeQshj6ASGWZFhkNgais4KXIk5jlsYYIBONECEUFi3aJE1oChV0ORVGAYpyWbIaux97Otp-Ddr3cGJfrulaNbgcngcZcUMqZ8PTyD123g238dxIEQBgzYNSrm1HltnXO6lJ21myU3Uogcjex9BPLcWKPL_aVQ7bRxS_92dSDqxG0Q_df0Te4IoF5</recordid><startdate>201302</startdate><enddate>201302</enddate><creator>Yong, Kenneth</creator><creator>Dogra, Gursharan</creator><creator>Boudville, Neil</creator><creator>Chan, Doris</creator><creator>Adams, Leon</creator><creator>Ching, Helena</creator><creator>Lim, Ee M.</creator><creator>Lim, Wai H.</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201302</creationdate><title>Interleukin-12 Is Associated With Arterial Stiffness in Healthy Individuals</title><author>Yong, Kenneth ; Dogra, Gursharan ; Boudville, Neil ; Chan, Doris ; Adams, Leon ; Ching, Helena ; Lim, Ee M. ; Lim, Wai H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-17abbe6b2510abd4f6c983c8e171634066a26373406402f121734056dd1a342f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis - epidemiology</topic><topic>Atherosclerosis - physiopathology</topic><topic>Biomarkers - blood</topic><topic>Cholesterol</topic><topic>Cross-Sectional Studies</topic><topic>Cytokines</topic><topic>Female</topic><topic>Humans</topic><topic>Interleukin-12 - blood</topic><topic>Interleukin-12 - physiology</topic><topic>Interleukin-18 - blood</topic><topic>Interleukin-18 - physiology</topic><topic>Male</topic><topic>Medical research</topic><topic>Middle Aged</topic><topic>Pulse Wave Analysis</topic><topic>Regression Analysis</topic><topic>Risk Factors</topic><topic>Vascular Stiffness - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yong, Kenneth</creatorcontrib><creatorcontrib>Dogra, Gursharan</creatorcontrib><creatorcontrib>Boudville, Neil</creatorcontrib><creatorcontrib>Chan, Doris</creatorcontrib><creatorcontrib>Adams, Leon</creatorcontrib><creatorcontrib>Ching, Helena</creatorcontrib><creatorcontrib>Lim, Ee M.</creatorcontrib><creatorcontrib>Lim, Wai H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yong, Kenneth</au><au>Dogra, Gursharan</au><au>Boudville, Neil</au><au>Chan, Doris</au><au>Adams, Leon</au><au>Ching, Helena</au><au>Lim, Ee M.</au><au>Lim, Wai H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-12 Is Associated With Arterial Stiffness in Healthy Individuals</atitle><jtitle>American journal of hypertension</jtitle><stitle>AJHYPE</stitle><addtitle>Am J Hypertens</addtitle><date>2013-02</date><risdate>2013</risdate><volume>26</volume><issue>2</issue><spage>159</spage><epage>162</epage><pages>159-162</pages><issn>0895-7061</issn><eissn>1941-7225</eissn><coden>AJHYE6</coden><abstract>BACKGROUND
Atherosclerotic cardiovascular disease (CVD) is a chronic inflammatory disease mediated by the proinflammatory cytokines interleukin-12 (IL-12) and interleukin-18 (IL-18). Evidence suggests that IL-12 is dominant in early atherosclerosis, while IL-18 is critical in advanced atherosclerosis. In this study, we explore the association between IL-12 and IL-18 and arterial stiffness in healthy individuals.
METHODS
We performed a cross-sectional study examining pulse wave velocity (PWV), augmentation index (AIx), IL-12, and IL-18 in healthy individuals (N = 53) without CVD risk factors.
RESULTS
In multivariate regression, age (P < 0.01), systolic blood pressure (P = 0.05), and IL-12 (P < 0.01) were positively associated with PWV, and high-density lipoprotein (P = 0.04) was negatively associated with PWV (model R
2 = 0.476, P < 0.01).
CONCLUSIONS
IL-12, but not IL-18, is associated with PWV in healthy individuals without clinical CVD, supporting a role for IL-12 in early atherosclerosis as suggested by animal studies.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>23382399</pmid><doi>10.1093/ajh/hps032</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0895-7061 |
| ispartof | American journal of hypertension, 2013-02, Vol.26 (2), p.159-162 |
| issn | 0895-7061 1941-7225 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1284622436 |
| source | Oxford University Press:Jisc Collections:OUP Read and Publish 2024-2025 (2024 collection) (Reading list) |
| subjects | Adult Atherosclerosis Atherosclerosis - epidemiology Atherosclerosis - physiopathology Biomarkers - blood Cholesterol Cross-Sectional Studies Cytokines Female Humans Interleukin-12 - blood Interleukin-12 - physiology Interleukin-18 - blood Interleukin-18 - physiology Male Medical research Middle Aged Pulse Wave Analysis Regression Analysis Risk Factors Vascular Stiffness - physiology |
| title | Interleukin-12 Is Associated With Arterial Stiffness in Healthy Individuals |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T20%3A49%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Interleukin-12%20Is%20Associated%20With%20Arterial%20Stiffness%20in%20Healthy%20Individuals&rft.jtitle=American%20journal%20of%20hypertension&rft.au=Yong,%20Kenneth&rft.date=2013-02&rft.volume=26&rft.issue=2&rft.spage=159&rft.epage=162&rft.pages=159-162&rft.issn=0895-7061&rft.eissn=1941-7225&rft.coden=AJHYE6&rft_id=info:doi/10.1093/ajh/hps032&rft_dat=%3Cproquest_cross%3E1284622436%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c381t-17abbe6b2510abd4f6c983c8e171634066a26373406402f121734056dd1a342f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1611583132&rft_id=info:pmid/23382399&rft_oup_id=10.1093/ajh/hps032&rfr_iscdi=true |