Simple Strategy to Functionalize Polymeric Substrates via Surface-Initiated ATRP for Biomedical Applications

The functionalization of polymer surfaces via surface-initiated atom transfer radical polymerization (ATRP) is of crucial importance to prepare various functional materials. It is generally complicated to conduct ATRP on different organic material surfaces. In this work, a facile photoinduced one-st...

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Bibliographic Details
Published in:Langmuir 2013-02, Vol.29 (5), p.1541-1550
Main Authors: Li, C. Y, Xu, F. J, Yang, W. T
Format: Article
Language:English
Subjects:
Antigen-Antibody Reactions
Applied sciences
Exact sciences and technology
Immunoglobulin G - chemistry
Immunoglobulin G - immunology
Organic polymers
Physicochemistry of polymers
Polymerization
Polymers - chemical synthesis
Polymers - chemistry
Properties and characterization
Surface Properties
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Summary:The functionalization of polymer surfaces via surface-initiated atom transfer radical polymerization (ATRP) is of crucial importance to prepare various functional materials. It is generally complicated to conduct ATRP on different organic material surfaces. In this work, a facile photoinduced one-step method was first developed for the covalent immobilization of ATRP initiators on the C–H group-containing substrates such as biaxially oriented polypropylene (BOPP). The C–H bonds of precise location of inert polymer surfaces were readily transferred to bromoalkyl initiator, followed by ATRP of 2-(dimethylamino)­ethyl methacrylate (DMAEMA) and glycidyl methacrylate (GMA), respectively, to produce the resultant patterned BOPP-g-P­(DMAEMA) and BOPP-g-P­(GMA) films. The epoxy groups of the P­(GMA) microdomains can be aminated for covalently coupling IgG, while the P­(DMAEMA) microdomains were used for immobilizing IgG via electronic interactions. The resultant IgG-coupled microdomains could interact with the corresponding target proteins, anti-IgG.
ISSN:0743-7463
1520-5827
DOI:10.1021/la302866n