Regulation of GPCR-mediated smooth muscle contraction: Implications for asthma and pulmonary hypertension

Abstract Contractile G-protein-coupled receptors (GPCRs) have emerged as key regulators of smooth muscle contraction, both under healthy and diseased conditions. This brief review will discuss some key topics and novel insights regarding GPCR-mediated airway and vascular smooth muscle contraction as...

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Bibliographic Details
Published in:Pulmonary pharmacology & therapeutics 2013-02, Vol.26 (1), p.121-131
Main Authors: Wright, D.B, Tripathi, S, Sikarwar, A, Santosh, K.T, Perez-Zoghbi, J, Ojo, O.O, Irechukwu, N, Ward, J.P.T, Schaafsma, D
Format: Article
Language:English
Subjects:
Animals
Asthma - physiopathology
Ca2+-mobilization
Ca2+-sensitization
Calcium
Calcium - metabolism
CPI-17
Humans
Hypertension, Pulmonary - physiopathology
Medical Education
Muscle Contraction - physiology
Muscle, Smooth - metabolism
Muscle, Smooth, Vascular - metabolism
Palmitoylation
Pulmonary/Respiratory
Receptors, G-Protein-Coupled - metabolism
ROCK
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Summary:Abstract Contractile G-protein-coupled receptors (GPCRs) have emerged as key regulators of smooth muscle contraction, both under healthy and diseased conditions. This brief review will discuss some key topics and novel insights regarding GPCR-mediated airway and vascular smooth muscle contraction as discussed at the 7th International Young Investigators' Symposium on Smooth Muscle (2011, Winnipeg, Manitoba, Canada) and will in particular focus on processes driving Ca2+ -mobilization and -sensitization.
ISSN:1094-5539
1522-9629
DOI:10.1016/j.pupt.2012.06.005