Endocrine Metabolic Disorders in Patients with Breast Cancer, Carriers of BRCA1 Gene Mutations

• Published in: Bulletin of experimental biology and medicine 2012-03, Vol.152 (5), p.610-612
• Main Authors: Berstein, L. M., Boyarkina, M. P., Vasilyev, D. A., Poroshina, T. E., Kovalenko, I. G., Imyanitov, E. N., Semiglazov, V. F.
• Format: Article
• Language: English
• Subjects: Biomedical and Life Sciences; Biomedicine; Blood Glucose - analysis; Blood levels; BRCA1 protein; BRCA1 Protein - genetics; BRCA1 Protein - metabolism; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; C-Peptide - blood; Cancer; Care and treatment; Cell Biology; Cholesterol; Dextrose; Endocrine System - metabolism; Endocrine System - pathology; Estradiol; Estradiol - blood; Estrogen; Estrogens; Excretion; Female; Gene mutations; Genes; Genetic aspects; Genotoxicity; Globulins; Glucose; Hormones; Humans; Hydroxyestrones - urine; Insulin; Insulin - blood; Insulin Resistance; Insulin-like growth factor I; Insulin-Like Growth Factor I - metabolism; Internal Medicine; Laboratory Medicine; Lipoproteins; Lipoproteins - blood; Metabolic disorders; Middle Aged; Mutation; Oncology; Pathology; Reactive oxygen species; Reactive Oxygen Species - blood; Remission; Sex; Sex Hormone-Binding Globulin - metabolism; Thyrotropin - blood; Triglycerides; Triglycerides - blood
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-012-1588-9

Two groups of breast cancer patients (53 ± 2 years) in clinical remission receiving no specific therapy were examined: group 1, with BRCA1 gene mutations ( N  = 11) and group 2, without mutations of this kind ( N  = 11). The two groups did not differ by insulinemia and glycemia, insulin resistance index, blood levels of thyrotropic hormone, sex hormone-binding globulin, insulin-like growth factor-1, triglycerides, or lipoproteins. In group 1, blood estradiol level was higher. Intensive glucose-induced generation of reactive oxygen species in these patients was associated with a decrease of cholesterolemia, of the C-peptide/insulin proportion, and a trend to higher urinary excretion of 4-hydroxyestrone, one of the most genotoxic catecholestrogens. BRCA1 gene mutations in breast cancer patients were associated with signs of estrogenization and a pro-genotoxic shift in the estrogen and glucose system, which could modulate the disease course and requires correction.