A New Rat Model of Reversible Global Cerebral Ischemia

A new rat model of global cerebral ischemia–reperfusion was proposed via reversible occlusion of the major vessels originating from the aortic arch and supplying the brain. This technique can be used for the search and study of exogenous (pharmacological) and endogenous methods of brain protection f...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2012-03, Vol.152 (5), p.656-658
Main Authors: Shcherbak, N. S., Galagudza, M. M., Kuzmenkov, A. N., Ovchinnikov, D. A., Mitrofanova, L. B., Barantsevich, E. R., Shlyakhto, E. V.
Format: Article
Language:English
Subjects:
Animal models
Animals
Aorta - pathology
Aorta - physiopathology
Aortic arch
Biomedical and Life Sciences
Biomedicine
Brain
Brain - pathology
Brain - physiopathology
Brain injury
Brain Ischemia - mortality
Brain Ischemia - pathology
Brain Ischemia - physiopathology
Carotid Arteries - pathology
Carotid Arteries - physiopathology
Cell Biology
Cerebral blood flow
Cerebral ischemia
Disease Models, Animal
Health aspects
Histocytochemistry
Internal Medicine
Ischemia
Laboratory Medicine
Ligation
Male
Pathology
Rats
Rats, Wistar
Reperfusion Injury - mortality
Reperfusion Injury - pathology
Reperfusion Injury - physiopathology
Survival Rate
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Description
Summary:A new rat model of global cerebral ischemia–reperfusion was proposed via reversible occlusion of the major vessels originating from the aortic arch and supplying the brain. This technique can be used for the search and study of exogenous (pharmacological) and endogenous methods of brain protection from ischemia–reperfusion injury.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-012-1600-4