A dual-emission and large Stokes shift fluorescence probe for real-time discrimination of ROS/RNS and imaging in live cells

A novel dual-emission fluorescence probe has been developed for specific and sensitive detection of hypochlorite (ClO(-)). Upon addition of ClO(-), significant changes in fluorescence emission intensity at two discrete wavelengths were observed. Meanwhile OONO(-) led to only a single-channel fluores...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2013-01, Vol.49 (18), p.1862-1864
Main Authors: Guo, Ting, Cui, Lei, Shen, Jiaoning, Wang, Rui, Zhu, Weiping, Xu, Yufang, Qian, Xuhong
Format: Article
Language:English
Subjects:
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
HeLa Cells
Humans
Molecular Structure
Reactive Nitrogen Species - chemistry
Reactive Nitrogen Species - metabolism
Reactive Oxygen Species - chemistry
Reactive Oxygen Species - metabolism
Time Factors
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Summary:A novel dual-emission fluorescence probe has been developed for specific and sensitive detection of hypochlorite (ClO(-)). Upon addition of ClO(-), significant changes in fluorescence emission intensity at two discrete wavelengths were observed. Meanwhile OONO(-) led to only a single-channel fluorescence enhancement. This feature makes it a clear advantage in distinguishing ClO(-), RNS from other ROS.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc38471c