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Recent progress in biocatalysis using supercritical carbon dioxide

The latest advances in biocatalysis using supercritical carbon dioxide (scCO2) are reviewed. Stability and stabilization methodologies of enzymes in scCO2 as well as reactions for organic synthesis are described. Especially, varieties of examples for lipase-catalyzed synthesis of chiral compounds us...

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Published in:Journal of bioscience and bioengineering 2013-03, Vol.115 (3), p.233-241
Main Author: Matsuda, Tomoko
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Language:English
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description The latest advances in biocatalysis using supercritical carbon dioxide (scCO2) are reviewed. Stability and stabilization methodologies of enzymes in scCO2 as well as reactions for organic synthesis are described. Especially, varieties of examples for lipase-catalyzed synthesis of chiral compounds using scCO2 are given. Furthermore, asymmetric reduction by alcohol dehydrogenase in scCO2 and carboxylation by decarboxylase in scCO2 are also introduced.
doi_str_mv 10.1016/j.jbiosc.2012.10.002
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ispartof Journal of bioscience and bioengineering, 2013-03, Vol.115 (3), p.233-241
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1347-4421
language eng
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subjects Alcohol dehydrogenase
Alcohol Dehydrogenase - metabolism
Asymmetric synthesis
Biocatalysis
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
Candida antarctica lipase B
Carbon dioxide
Carbon Dioxide - chemistry
carboxylation
Chemistry Techniques, Synthetic
decarboxylases
Enzyme
Enzyme Stability
Fundamental and applied biological sciences. Psychology
Geotrichum candidum
Lipase - metabolism
lipases
Methods. Procedures. Technologies
Novozym 435
Organic synthesis
Solvents - chemistry
Supercritical fluid
title Recent progress in biocatalysis using supercritical carbon dioxide
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