The Effect of Cardiopulmonary Bypass and Hypothermic Circulatory Arrest on Hepatic Histology in Newborn Animals: An Experimental Study

Still little is known about the effect of cardiac surgery on neonatal hepatic tissue. We examined the effect of cardiopulmonary bypass (CPB) and the effect of deep hypothermic circulatory arrest (DHCA) on neonatal hepatic tissue. Liver biopsies of neonatal piglets were taken after CPB (n = 4), after...

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Bibliographic Details
Published in:Artificial organs 2013-01, Vol.37 (1), p.E35-E39
Main Authors: Tirilomis, Theodor, Zwiehoff, Julia M., Waldmann-Beushausen, Regina, Schneider, Simon, Schoendube, Friedrich A.
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Animals, Newborn
Apoptosis
Biopsy
Cardiopulmonary Bypass
Circulatory Arrest, Deep Hypothermia Induced
Edema
Edema - pathology
Hepatic tissue
Hypothermia
Inflammation - pathology
Liver - pathology
Neonatal
Staining and Labeling
Swine
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Summary:Still little is known about the effect of cardiac surgery on neonatal hepatic tissue. We examined the effect of cardiopulmonary bypass (CPB) and the effect of deep hypothermic circulatory arrest (DHCA) on neonatal hepatic tissue. Liver biopsies of neonatal piglets were taken after CPB (n = 4), after DHCA (n = 5), and after surgery without CPB (non‐CPB; n = 3). Additionally, findings were compared to those of control piglets (n = 9). The liver specimens were fixed, stained with hematoxylin and eosin, and scored regarding inflammatory reaction, hepatocellular edema, and apoptosis. Inflammation score of treated groups was higher than in control; CPB 2.5 ± 0.5, DHCA 1.6 ± 0.4, non‐CPB 1.2 ± 0.6, control 0.4 ± 0.3 (P 
ISSN:0160-564X
1525-1594
DOI:10.1111/j.1525-1594.2012.01577.x