Chronic Hepatitis E as a cause for cryptogenic cirrhosis in HIV

Summary Chronic Hepatitis E infection (HEV) is reported in immunocompromised patients. A 45-year-old HIV-infected man had no cause found for a persistent transaminitis which predated commencement of antiretroviral therapy. Hepatic elastography and liver biopsy revealed cirrhosis. In 2010, he tested...

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Bibliographic Details
Published in:The Journal of infection 2013-01, Vol.66 (1), p.103-106
Main Authors: Jagjit Singh, Gurmit K, Ijaz, Samreen, Rockwood, Neesha, Farnworth, Simon P, Devitt, Emma, Atkins, Mark, Tedder, Richard, Nelson, Mark
Format: Article
Language:English
Subjects:
Antiviral Agents - therapeutic use
Biological and medical sciences
Biopsy
Elasticity Imaging Techniques
General aspects
Hepatitis Antibodies - blood
Hepatitis E
Hepatitis E - blood
Hepatitis E - drug therapy
Hepatitis E - virology
Hepatitis E virus
Hepatitis, Chronic - blood
Hepatitis, Chronic - drug therapy
Hepatitis, Chronic - virology
HIV
HIV Infections - blood
HIV Infections - drug therapy
HIV Infections - virology
Human viral diseases
Humans
Immunosuppression
Infectious Disease
Infectious diseases
Interferon-alpha - therapeutic use
Liver
Liver Cirrhosis - blood
Liver Cirrhosis - drug therapy
Liver Cirrhosis - virology
Male
Medical sciences
Middle Aged
Pegylated interferon
Polyethylene Glycols - therapeutic use
Transaminitis
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral hepatitis
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Summary:Summary Chronic Hepatitis E infection (HEV) is reported in immunocompromised patients. A 45-year-old HIV-infected man had no cause found for a persistent transaminitis which predated commencement of antiretroviral therapy. Hepatic elastography and liver biopsy revealed cirrhosis. In 2010, he tested positive for HEV IgM/IgG antibodies. Plasma HEV RNA was detected. Archived samples revealed HEV viraemia since 2000. A 24-week course of pegylated interferon was commenced and HEV RNA became undetectable at week 4 until week 27 post treatment cessation. Chronic HEV infection should be considered in HIV patients as a cause for unexplained transaminitis and cryptogenic liver cirrhosis.
ISSN:0163-4453
1532-2742
DOI:10.1016/j.jinf.2011.11.027