Non-invasive ventilation in immunosuppressed patients with pneumonia and extrapulmonary sepsis

Summary Purpose International guidelines recommend the use of noninvasive ventilation in immunocompromised patients with acute respiratory failure (ARF). We analyzed failure rates and risk factors for NIV failure in immunocompromised patients. Methods We retrospectively analyzed 120 immunodeficient...

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Bibliographic Details
Published in:Respiratory medicine 2012-11, Vol.106 (11), p.1509-1516
Main Authors: Razlaf, Peter, Pabst, Dirk, Mohr, Michael, Kessler, Torsten, Wiewrodt, Rainer, Stelljes, Matthias, Reinecke, Holger, Waltenberger, Johannes, Berdel, Wolfgang E, Lebiedz, Pia
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Adult
Aged
Aged, 80 and over
Autoimmune diseases
Autoimmune Diseases - immunology
Biological and medical sciences
Bone marrow
Cell adhesion & migration
Critical Care
Disease
Feasibility Studies
Female
Gases
Hematologic Diseases - immunology
Humans
Immune Tolerance - physiology
Immunologic Deficiency Syndromes - immunology
Immunosuppressed patients
Immunosuppressive Agents - adverse effects
Intensive care
Intubation
Length of Stay
Male
Medical sciences
Middle Aged
Mortality
Multivariate analysis
Neuromuscular diseases
Non-invasive ventilation
Noninvasive Ventilation
Oxygen
Pathogenesis
Pneumology
Pneumonia
Pneumonia, Bacterial - immunology
Pulmonary/Respiratory
Respiratory Insufficiency - immunology
Respiratory Insufficiency - microbiology
Respiratory Insufficiency - therapy
Respiratory system : syndromes and miscellaneous diseases
Retrospective Studies
Risk Factors
Sepsis
Sepsis - immunology
SIRS and pneumonia
Statistical analysis
Systemic Inflammatory Response Syndrome - immunology
Transplantation Immunology
Ventilation
Young Adult
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Summary:Summary Purpose International guidelines recommend the use of noninvasive ventilation in immunocompromised patients with acute respiratory failure (ARF). We analyzed failure rates and risk factors for NIV failure in immunocompromised patients. Methods We retrospectively analyzed 120 immunodeficient patients treated with NIV in our medical ICU from 2005 to 2011. We compared the clinical course and NIV failure rates. Furthermore, we compared patients with secondary respiratory failure due to those with Systemic Inflammatory Response Syndrome (SIRS) of other than pulmonary origin to those with primary pulmonary infiltrations. Results Regression analyses revealed high APACHE II score ( p  
ISSN:0954-6111
1532-3064
DOI:10.1016/j.rmed.2012.08.007