Association between Obstructive Sleep Apnea and Cancer Incidence in a Large Multicenter Spanish Cohort

Obstructive sleep apnea (OSA) has been associated with increased cancer mortality, but whether it is also associated with cancer incidence is unknown. To investigate whether OSA is associated with increased cancer incidence in a large clinical cohort. A multicenter, clinical cohort study including c...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2013, Vol.187 (1), p.99-105
Main Authors: CAMPOS-RODRIGUEZ, Francisco, MARTINEZ-GARCIA, Miguel A, BARBE, Ferran, MONTSERRAT, Jose M, FARRE, Ramon, MARTINEZ, Montserrat, DURAN-CANTOLLA, Joaquin, DE LA PENA, Monica, MASDEU, Maria J, GONZALEZ, Monica, DEL CAMPO, Felix, GALLEGO, Inmaculada, MARIN, Jose M
Format: Article
Language:English
Subjects:
Age Factors
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Cancer
Clinical death. Palliative care. Organ gift and preservation
Cohort analysis
Electrocardiography
Female
Humans
Hypoxia
Incidence
Intensive care medicine
Male
Medical prognosis
Medical records
Medical sciences
Middle Aged
Mortality
Neoplasms - epidemiology
Patients
Retrospective Studies
Sex Factors
Sleep apnea
Sleep Apnea, Obstructive - epidemiology
Spain - epidemiology
Teaching hospitals
Thoracic surgery
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Summary:Obstructive sleep apnea (OSA) has been associated with increased cancer mortality, but whether it is also associated with cancer incidence is unknown. To investigate whether OSA is associated with increased cancer incidence in a large clinical cohort. A multicenter, clinical cohort study including consecutive patients investigated for suspected OSA between 2003 and 2007 in seven Spanish teaching hospitals. Apnea-hypopnea index (AHI) and percent nighttime with oxygen saturation less than 90% (TSat(90)) were used as surrogates of OSA severity, both as continuous variables and categorized by tertiles. Cox proportional hazards regression analyses were used to calculate hazard ratio (HR) and 95% confidence interval (CI) for cancer incidence after adjusting for confounding variables. A total of 4,910 patients were analyzed (median follow-up, 4.5 yr; interquartile range, 3.4-5.2). Compared with the lower TSat(90) category (43 vs.
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.201209-1671oc