Effects of the herbal medicine composition “Saiko-ka-ryukotsu-borei-To” on the function of endothelial progenitor cells in hypertensive rats

Endothelial progenitor cells (EPCs) are known to repair vascular injuries. Recent studies suggest that Saiko-ka-ryukotsu-borei-To (SKRBT), a traditional herbal medicine that has been used to treat stress-related neuropsychiatric disorders, has protective effects on cardiovascular diseases such as hy...

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Bibliographic Details
Published in:Phytomedicine (Stuttgart) 2013-02, Vol.20 (3-4), p.196-201
Main Authors: Iijima, Hiroshi, Daikonya, Akihiro, Takamatsu, Satoshi, Kanno, Ai, Magariyama, Kayoko, Yoshikawa, Kazuki, Takamiya, Tomoko, Ueda, Yukiko, Yakubo, Shuji, Matsumoto, Taro, Ueno, Takahiro, Yamori, Yukio, Fukuda, Noboru, Kitanaka, Susumu
Format: Article
Language:English
Subjects:
Animals
Bone Marrow Cells - drug effects
Cardiovascular diseases
Care and treatment
Chemical properties
Cytokines - blood
Drug Evaluation, Preclinical
Drugs, Chinese Herbal - pharmacology
Drugs, Chinese Herbal - therapeutic use
Endothelial Cells - drug effects
Endothelial progenitor cell
Epithelial cells
Health aspects
Hypertension
Hypertension - prevention & control
IL-6
Leukocytes, Mononuclear - metabolism
Male
Medicine, Botanic
Medicine, Herbal
NADPH Oxidases - metabolism
Oxidative stress
Phytotherapy
Prevention
Rats
Rats, Inbred SHR
Reactive Oxygen Species - metabolism
Risk factors
RNA, Messenger - metabolism
Saiko-ka-ryukotsu-borei-To
Spontaneously hypertensive rat
Thiobarbituric Acid Reactive Substances - metabolism
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Summary:Endothelial progenitor cells (EPCs) are known to repair vascular injuries. Recent studies suggest that Saiko-ka-ryukotsu-borei-To (SKRBT), a traditional herbal medicine that has been used to treat stress-related neuropsychiatric disorders, has protective effects on cardiovascular diseases such as hypertension and arteriosclerosis. Spontaneously hypertensive rats (SHRs) were fed diets containing lyophilized SKRBT extract for 6 weeks. Peripheral blood mononuclear cells (MNCs) were isolated and cultured to assay EPC colony formation. Oxidative stress in MNCs was evaluated by thiobarbituric acid reactive substance (TBARS) assay and flowcytometric analyses. Treatment with SKRBT increased EPC colony numbers significantly (p
ISSN:0944-7113
1618-095X
DOI:10.1016/j.phymed.2012.10.014