Protective Effects of Nigella sativa Oil in Hyperoxia-Induced Lung Injury

BACKGROUNDOxygen-induced lung injury is believed to lead to the development of bronchopulmonary dysplasia in premature infants. We have evaluated the beneficial effects of Nigella sativa oil (NSO) on rats with hyperoxia-induced lung injury.METHODSThirty newborn Sprague-Dawley rats were randomly divi...

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Published in:Archivos de bronconeumología (English ed.) 2013-01, Vol.49 (1), p.15-21
Main Authors: Tayman, Cuneyt, Cekmez, Ferhat, Kafa, Ilker Mustafa, Canpolat, Fuat Emre, Cetinkaya, Merih, Tonbul, Alparslan, Uysal, Sema, Tunc, Turan, Sarici, S Umit
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Language:eng ; spa
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Summary:BACKGROUNDOxygen-induced lung injury is believed to lead to the development of bronchopulmonary dysplasia in premature infants. We have evaluated the beneficial effects of Nigella sativa oil (NSO) on rats with hyperoxia-induced lung injury.METHODSThirty newborn Sprague-Dawley rats were randomly divided into 3 groups as hyperoxia (95% O(2)), hyperoxia+NSO and control (21% O(2)). Pups in the hyperoxia+NSO group were administered intraperitoneal NSO at a dose of 4ml/kg daily during the study period. Histopathologic, immunochemical, and biochemical evaluations (superoxide dismutase [SOD], glutathione peroxidase [GSH-Px], malonaldehyde [MDA] and myeloperoxidase [MPO]) were performed.RESULTSIn the histopathologic and immunochemical evaluation, severity of lung damage was significantly lower in the hyperoxia+NOS group (P
ISSN:1579-2129
DOI:10.1016/j.arbres.2012.03.013