PDGF α receptor is a mediator for Cisplatin-induced Met expression

For decades, platinum drugs have been the mainstay of cancer treatment. However, over time, drug resistance develops, leaving few treatment options. Here we show that platelet-derived growth factor α receptor (PDGF α receptor)-mediated signaling plays a key role in hepatocyte growth factor (HGF) rec...

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Bibliographic Details
Published in:European journal of pharmacology 2013-01, Vol.699 (1-3), p.227-232
Main Authors: Kina, Shinichiro, Phonaphonh, Thongsavanh, Liang, Feixin, Kuang, Hai, Arasaki, Akira, Arakaki, Keiichi, Nakasone, Toshiyuki, Sunakawa, Hajime
Format: Article
Language:English
Subjects:
Antineoplastic Agents - pharmacology
Cell Line, Tumor
Cisplatin
Cisplatin - pharmacology
Drug Resistance, Neoplasm
Female
Gene Expression Regulation, Neoplastic - drug effects
Humans
Met
PDGF receptor
Proto-Oncogene Proteins c-met - genetics
Receptor, Platelet-Derived Growth Factor alpha - antagonists & inhibitors
Receptor, Platelet-Derived Growth Factor alpha - metabolism
Signal Transduction
Up-Regulation - drug effects
Uterine Cervical Neoplasms - drug therapy
Uterine Cervical Neoplasms - genetics
Uterine Cervical Neoplasms - pathology
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Summary:For decades, platinum drugs have been the mainstay of cancer treatment. However, over time, drug resistance develops, leaving few treatment options. Here we show that platelet-derived growth factor α receptor (PDGF α receptor)-mediated signaling plays a key role in hepatocyte growth factor (HGF) receptor (c-Met) upregulation, which in turn is thought to play an important role in chemotherapy resistance. PDGF α receptor inhibition eliminates cisplatin-dependent Met expression in cervical cancer cell lines. PDGF α receptor inhibitors are widely used in clinical settings, suggesting that the clinical translation of our findings could reduce the suffering of people from drug resistance.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2012.11.014