Compositional characterisation of soluble apple polysaccharides, and their antioxidant and hepatoprotective effects on acute CCl4-caused liver damage in mice

► Both APP and AFP were acidic polysaccharides from Pink Lady apple peel and flesh. ► Both APP and AFP exerted significant hepatoprotection from CCl4-induced damage in mice. ► The hepatoprotection of APP and AFP was mediated by antioxidant mechanism in mice. ► Histopathological tests show the protec...

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Bibliographic Details
Published in:Food chemistry 2013-06, Vol.138 (2-3), p.1256-1264
Main Authors: Yang, Xingbin, Yang, Su, Guo, Yurong, Jiao, Yadong, Zhao, Yan
Format: Article
Language:English
Subjects:
Animals
Antioxidant activity
Antioxidants - chemistry
Antioxidants - metabolism
Apple polysaccharides
Biological and medical sciences
Carbon Tetrachloride - adverse effects
Food industries
Fruit and vegetable industries
Fundamental and applied biological sciences. Psychology
Hepatocytes - drug effects
Hepatocytes - metabolism
Hepatoprotective effect
HPLC
Humans
Liver - drug effects
Liver - injuries
Liver - metabolism
Liver Diseases - diet therapy
Liver Diseases - etiology
Liver Diseases - metabolism
Male
Malondialdehyde - metabolism
Malus - chemistry
Malus - metabolism
Mice
Peel and flesh
Plant Extracts - chemistry
Plant Extracts - metabolism
Polysaccharides - chemistry
Polysaccharides - metabolism
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Summary:► Both APP and AFP were acidic polysaccharides from Pink Lady apple peel and flesh. ► Both APP and AFP exerted significant hepatoprotection from CCl4-induced damage in mice. ► The hepatoprotection of APP and AFP was mediated by antioxidant mechanism in mice. ► Histopathological tests show the protection from CCl4 caused histological alteration. Water-soluble apple peel polysaccharides (APP) and apple flesh polysaccharides (AFP) were isolated from Pink Lady fruits, and their in vitro antioxidant capacities were characterised by DPPH, HO, and O2− systems, and ferric-reducing antioxidant power assay. Oral administration of APP at 250 and 500mg/kg bw in mice was shown to be as effective as AFP in lowering the CCl4-caused increases of serum alanine aminotransferase, aspartate aminotransferase and lactic dehydrogenase activities, and hepatic malondialdehyde level, and antagonising the decreases in antioxidant superoxide dismutase and glutathione peroxidase activities caused by CCl4 (p
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2012.10.030