FTO and MC4R gene variants determine BMI changes in children after intensive lifestyle intervention

• Published in: Clinical biochemistry 2013-03, Vol.46 (4-5), p.313-316
• Main Authors: Zlatohlavek, L., Vrablik, M., Motykova, E., Ceska, R., Vasickova, L., Dlouha, D., Hubacek, J.A.
• Format: Article
• Language: English
• Subjects: Adolescent; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; BMI; Body Mass Index; Child; Children; Diet, Reducing; Energy Intake; Epistasis, Genetic; Exercise Therapy; Female; FTO; Gene Frequency; Genetic Association Studies; Humans; Lifestyle intervention; Male; MC4R; Obesity; Obesity - genetics; Obesity - therapy; Overweight - genetics; Overweight - therapy; Polymorphism; Polymorphism, Genetic; Proteins - genetics; Receptor, Melanocortin, Type 4 - genetics; Sequence Analysis, DNA; Weight Reduction Programs
• ISSN: 0009-9120; 1873-2933
• DOI: 10.1016/j.clinbiochem.2012.11.017

This study aimed to determine whether there is a relationship between common FTO (rs17817449) and MC4R (rs17782313) gene variants and body mass reduction or weight loss after a one-month lifestyle intervention in overweight/obese children. We genotyped 357 unrelated non-diabetic Czech children (age 13.7±4.9years, average BMI at baseline 30.8±4.6kg/m2). Biochemical and anthropometrical measurements were performed before and after 4weeks of lifestyle interventions (comprising a reduction in energy intake to the age-matched optimum and a supervised exercise program consisting of 5 exercise units per day, 50min each). The mean weight loss achieved was 6.2±2.1kg (P