Enhanced oxidative stress in Hashimoto's thyroiditis: Inter-relationships to biomarkers of thyroid function

Oxidative stress has been implicated in the pathogenesis of several inflammatory and immune-mediated disorders including Hashimoto's thyroiditis (HT). The objectives of the present cross-sectional investigation were to estimate serum glutathione (GSH) status and the activities of its recycling...

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Bibliographic Details
Published in:Clinical biochemistry 2013-03, Vol.46 (4-5), p.308-312
Main Authors: Rostami, R., Aghasi, M.R., Mohammadi, A., Nourooz-Zadeh, J.
Format: Article
Language:English
Subjects:
Adult
Autoantibodies - blood
Autoantigens - immunology
Biomarkers - blood
Case-Control Studies
Cellular antioxidants
Female
gamma-Glutamyltransferase - blood
Glutathione
Glutathione - blood
Glutathione Peroxidase - blood
Glutathione Reductase - blood
Hashimato's thyroiditis
Hashimoto Disease - blood
Hashimoto Disease - immunology
Hashimoto Disease - urine
Humans
Iodide Peroxidase - immunology
Iodine
Iodine - urine
Iron-Binding Proteins - immunology
Oxidative Stress
Thyroid Gland - physiopathology
Thyrotropin - blood
Young Adult
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Summary:Oxidative stress has been implicated in the pathogenesis of several inflammatory and immune-mediated disorders including Hashimoto's thyroiditis (HT). The objectives of the present cross-sectional investigation were to estimate serum glutathione (GSH) status and the activities of its recycling enzymes in HT and to explore their interrelationships with biomarkers of autoimmunity and thyroid function. Newly diagnosed females with HT (n=44) and 58 matched control subjects were recruited. Thyroid hormone profile, anti-thyroperoxidase anti-body (TPO-AB), anti-thyroglublin antibody (Tg-AB), thyroid volume (Tvol), urinary iodine excretion (UIE), GSH and the activities of glutathione peroxidase (GPx), glutathione reductase and gamma-glutamyltransferase were assessed. Median UIE in HT was slightly but not significantly higher than that of controls. HT group exhibited higher levels of TSH, TPO-AB, Tg-AB and larger Tvol when compared with controls (P
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2012.11.021