Phosphoinositide 3-kinase γ mediates microglial phagocytosis via lipid kinase-independent control of cAMP

Graphical abstract Highlights ► PI3Kγ controls microglial phagocytosis of bacteria and Zymosan particles. ► PI3Kγ affects microglial phagocytosis via stimulation of cAMP phosphodiesterase (PDE). ► Inhibitors of PI3Kγ and PDE suppress microglial phagocytosis of viable neurons. ► Inhibitors of PI3Kγ a...

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Bibliographic Details
Published in:Neuroscience 2013-03, Vol.233, p.44-53
Main Authors: Schmidt, C, Schneble, N, Müller, J.P, Bauer, R, Perino, A, Marone, R, Rybalkin, S.D, Wymann, M.P, Hirsch, E, Wetzker, R
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain - cytology
Brain - enzymology
Brain - immunology
cAMP
Class Ib Phosphatidylinositol 3-Kinase - metabolism
Cyclic AMP - metabolism
Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism
Fundamental and applied biological sciences. Psychology
Isolated neuron and nerve. Neuroglia
Lipid Metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
microglia
Microglia - enzymology
Microglia - immunology
Neurology
PDE
phagocytosis
Phagocytosis - physiology
PI3K
Second Messenger Systems - physiology
Signal Transduction - physiology
Vertebrates: nervous system and sense organs
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Summary:Graphical abstract Highlights ► PI3Kγ controls microglial phagocytosis of bacteria and Zymosan particles. ► PI3Kγ affects microglial phagocytosis via stimulation of cAMP phosphodiesterase (PDE). ► Inhibitors of PI3Kγ and PDE suppress microglial phagocytosis of viable neurons. ► Inhibitors of PI3Kγ and PDE might be used for treatment of neurodegenerative diseases.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.12.036