Chemotherapy, targeted agents, antiemetics and growth-factors in human milk: How should we counsel cancer patients about breastfeeding?

Abstract An increasing number of women are diagnosed with cancer during pregnancy and lactation. Women are usually advised to interrupt breastfeeding during systemic anticancer treatment for fear of serious adverse effects to the nursed infant. However, the issue is poorly addressed in the literatur...

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Bibliographic Details
Published in:Cancer treatment reviews 2013-05, Vol.39 (3), p.207-211
Main Authors: Pistilli, Barbara, Bellettini, Giulia, Giovannetti, Elisa, Codacci-Pisanelli, Giovanni, Azim, Hatem A, Benedetti, Giovanni, Sarno, Maria Anna, Peccatori, Fedro A
Format: Article
Language:English
Subjects:
Antiemetics
Antiemetics - adverse effects
Antiemetics - pharmacokinetics
Antineoplastic agents
Antineoplastic Agents - adverse effects
Antineoplastic Agents - pharmacokinetics
Biological and medical sciences
Breast Feeding
Breast Neoplasms - drug therapy
Breast Neoplasms - metabolism
Breastfeeding
Cancer
Chemotherapy
Drug-Related Side Effects and Adverse Reactions - chemically induced
Female
Growth factors
Hematology, Oncology and Palliative Medicine
Humans
Infant, Newborn
Intercellular Signaling Peptides and Proteins - adverse effects
Intercellular Signaling Peptides and Proteins - pharmacokinetics
Lactation - metabolism
Male
Medical sciences
Milk
Milk, Human - metabolism
Pharmacokinetics
Pharmacology. Drug treatments
Pregnancy
Pregnancy Complications, Neoplastic - drug therapy
Pregnancy Complications, Neoplastic - metabolism
Targeted agents
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Summary:Abstract An increasing number of women are diagnosed with cancer during pregnancy and lactation. Women are usually advised to interrupt breastfeeding during systemic anticancer treatment for fear of serious adverse effects to the nursed infant. However, the issue is poorly addressed in the literature and very few studies have evaluated the safety of breastfeeding during or after cytotoxic drugs or target agents administration. In this review we will analyze the available evidence that addresses the issue of anticancer drugs, targeted agents, antiemetics and growth-factors excretion in human milk. This could serve as a unique resource that may aid physicians in the management of breastfeeding cancer patients interested in maintaining lactation during treatment.
ISSN:0305-7372
1532-1967
DOI:10.1016/j.ctrv.2012.10.002