Loss of substance P and inflammation precede delayed neurodegeneration in the substantia nigra after cerebral ischemia

Highlight ► Early loss of substance P in the substantia nigra (SN) is accompanied with inflammation after experimental stroke and precedes cell death in the SN.

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2013-03, Vol.29, p.51-61
Main Authors: Rodriguez-Grande, Beatriz, Blackabey, Victoria, Gittens, Beatrice, Pinteaux, Emmanuel, Denes, Adam
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animal models
Animals
Brain
Brain Ischemia - metabolism
Brain Ischemia - pathology
Cell Death - physiology
Cerebral blood flow
Cerebral ischemia
Coloring Agents
Data processing
Dopaminergic Neurons - pathology
Immunohistochemistry
Infarction, Middle Cerebral Artery - pathology
Inflammation
Inflammation - pathology
Injuries
Ischemia
Male
Mice
Mice, Inbred C57BL
Motor Activity - physiology
Movement disorders
Neostriatum
Neostriatum - metabolism
Neostriatum - pathology
Neurodegeneration
Neurodegenerative diseases
Neurodegenerative Diseases - metabolism
Neurodegenerative Diseases - pathology
Neuronal-glial interactions
NK1 tachykinin receptor
Parkinson's disease
Psychiatry
Receptors, Neurokinin-1 - metabolism
Remote injury
Stroke
Substance P
Substance P - metabolism
Substantia nigra
Substantia Nigra - metabolism
Substantia Nigra - pathology
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Description
Summary:Highlight ► Early loss of substance P in the substantia nigra (SN) is accompanied with inflammation after experimental stroke and precedes cell death in the SN.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2012.11.017