Virological surveillance for early warning of dengue epidemics in the State of Rio de Janeiro, Brazil

Background The state of Rio de Janeiro has been important since 1986 as a portal for the introduction of dengue virus (DENV) into Brazil and dissemination of the virus throughout the country. This study describes an active surveillance of DENV in the state of Rio de Janeiro from 2004 to 2008. Method...

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Bibliographic Details
Published in:Transactions of the Royal Society of Tropical Medicine and Hygiene 2013-03, Vol.107 (3), p.141-146
Main Authors: Macedo, Gleicy Amorim, de Araújo, Josélio Maria Galvão, Schatzmayr, Hermann Gonçalves, Costa, Filipe Anibal Carvalho, de Filippis, Ana Maria Bispo, Santos, Flávia Barreto dos, Nogueira, Rita Maria Ribeiro
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Arboviroses
Biological and medical sciences
Brazil - epidemiology
Child
Child, Preschool
Dengue - blood
Dengue - epidemiology
Dengue fevers
Dengue Virus - isolation & purification
Female
General aspects
Human viral diseases
Humans
Infant
Infectious diseases
Male
Medical sciences
Middle Aged
Public Health Surveillance - methods
Tropical viral diseases
Viral diseases
Young Adult
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Summary:Background The state of Rio de Janeiro has been important since 1986 as a portal for the introduction of dengue virus (DENV) into Brazil and dissemination of the virus throughout the country. This study describes an active surveillance of DENV in the state of Rio de Janeiro from 2004 to 2008. Method A total of 14 408 samples from patients suspected to be infected with DENV were tested by virus isolation, and nested reverse transcriptase (RT)-PCR assay or anti-DENV dengue IgM antibody capture ELISA (MAC-ELISA), or both. Results By the use of these different methods, a total of 2324 (16.1%) cases were confirmed as dengue infection. The study covers an inter-epidemic period (2004-2005), the DENV-3 circulation in 2006, the re-emergence of DENV-2 in 2007 and the severe epidemic caused by DENV-2 in the summer of 2008. During the period, 69 dengue fatal cases were reported, 14 (20.2%) deaths being attributable to DENV-3 and 55 (79.7%) to DENV-2. Conclusion Our results emphasize the role of the laboratory in the early detection of dengue virus transmission and provide information on the dynamics of DENV introduction and spread, important for the assessment of intervention strategies.
ISSN:0035-9203
1878-3503
DOI:10.1093/trstmh/trs091