Lipopolysaccharide-induced anhedonia is abolished in male serotonin transporter knockout rats: An intracranial self-stimulation study

Highlight ► LPS-induced anhedonia is abolished in SERT−/− rats, suggesting that increased activity of SERT during inflammation plays a role in the development of depression.

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2013-03, Vol.29, p.98-103
Main Authors: van Heesch, Floor, Prins, Jolanda, Konsman, Jan Pieter, Westphal, Koen G.C, Olivier, Berend, Kraneveld, Aletta D, Korte, S. Mechiel
Format: Article
Language:English
Subjects:
Allergy and Immunology
alpha -Interferon
Analysis of Variance
Anhedonia
Anhedonia - drug effects
Anhedonia - physiology
Animals
Animals, Genetically Modified
Area Under Curve
Bacterial Toxins - pharmacology
Body weight
Body Weight - drug effects
Brain - physiology
Cytokines
Cytokines - pharmacology
Depression
Enterotoxins - pharmacology
Escherichia coli Proteins
Etiology
Gene Deletion
Genotypes
Hedonic response
Immune response
Inflammation
Intracranial self-stimulation
Lipopolysaccharide
Lipopolysaccharides
Lipopolysaccharides - pharmacology
Male
Psychiatry
Rats
Self Stimulation
Serotonin
Serotonin Plasma Membrane Transport Proteins - genetics
Serotonin Plasma Membrane Transport Proteins - physiology
Serotonin transporter
Serotonin transporter knockout
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Summary:Highlight ► LPS-induced anhedonia is abolished in SERT−/− rats, suggesting that increased activity of SERT during inflammation plays a role in the development of depression.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2012.12.013